妊娠高血压疾病孕妇血胱抑素C与尿素氮、肌酐检测结果的分析

Analysis of test values of serum cystatin C、BUN and Cr in hypertensive disorder complicating pregnancy

目的探讨孕妇血清胱抑素C(Cys C)、尿素氮(BUN)和肌酐(Cr)与妊娠期高血压疾病的关系。方法用日立7180全自动生化分析仪对50例妊娠期高血压疾病孕妇及50例妊娠中晚期正常孕妇进行血清Cys C、BUN、Cr的检测。结果重度及轻度子痫前期组Cys C值明显高于正常孕妇组(P<0.01),且有显著性差异,重度子痫前期组Cys C明显高于轻度子痫前期组,有显著性差异(P<0.05);而重度子痫前期组BUN、Cr明显高于正常孕妇组(P<0.01),有显著性差异,但轻度子痫前期组BUN、Cr与正常孕妇组相比,无显著性差异(P>0.05)。结论血清Cys C的检测对于妊娠期高血压疾病的肾功能损害具有较好的诊断价值,联合检测血清Cys C、BUN、Cr有利于HDCP及其并发的肾功能损害的诊断及监测。

Objective：To detect the serum cystatin C、usea nitrogen（BUN） and creatinine（Cr） in pregnancy and investigate the correlation between the test values and hypertensive disorder complicating pregnancy.Methods：The serum cystatin C、usea nitrogen（BUN） and creatinine（Cr） of 50 cases of pregnant women with hypertensive disorder complicating pregnancy and 50 cases of normal women in mid trimester or late trimester pregnancy were testes with eos-bravo.Results：The test values of serum cystatin C of pregnant women in severe pre-eclampsia and mild pre-eclampsia were higher obviously than the values of normal pregnant women.There was statistical significance of difference（P〈0.01）.and the test values of serum cystatin C of pregnant women in severe pre-eclampsia were higher than the test values in mild pre-eclampsia（P〈0.05）.The test values of usea nitrogen（BUN） and creatinine（Cr） of pregnant women in severe pre-eclampsia were higher obviously than the values of normal pregnant women.There was statistical significance of difference（P〈0.01）.There was not statistical significance of difference（P〉0.05） between the test values of usea nitrogen（BUN） and creatinine（Cr） of pregnant women in mild pre-eclampsia and the values of normal pregnant women.Conclusions：The levels of cystatin C would be utilized to estimate the degree of renal impairment which was induced of hypertensive disorder complicating pregnancy.So the joint detection of the serum cystatin C 、usea nitrogen（BUN） and creatinine（Cr） in pregnancy would be necessary for understanding the development of hypertensive disorder complicating pregnancy.