Livin、Smac和Ki67在上皮性卵巢癌中的表达及意义

Expressions and significances of Livin,Smac and Ki67 in epithelial ovarian carcinoma

目的:探讨凋亡抑制蛋白Livin、凋亡相关因子Smac和细胞增殖核抗原Ki67在上皮性卵巢癌的表达及临床意义,并分析三者的相关性。方法:利用免疫组化SP法检测50例上皮性卵巢癌、20例交界性卵巢肿瘤、20例良性卵巢肿瘤和20例正常卵巢组织中三者的表达情况。结果:Livin与Ki67在卵巢癌中的表达明显高于其他3组(P<0.01),在卵巢组织中的表达与组织病理学分级和有无淋巴结转移呈正相关(P<0.05),与组织学类型、分期无关。Smac在卵巢癌中的表达明显低于其他3组(P<0.01),在卵巢组织中的表达与组织病理学分级和有无淋巴结转移呈负相关(P<0.05),与组织学类型、分期无关。结论:Livin、Smac和Ki67在上皮性卵巢癌的发生、分化、进展过程中起重要作用;Livin、Smac和Ki67有望成为治疗卵巢癌的新靶点。

Objective：To explore the expressions and significances of inhibitor of apoptosis protein-Livin,apoptosis related factor-Smac and proliferating cell nuclear antigen-Ki67 in epithelial ovarian carcinoma,and analyze their correlation.Methods：Immunohistochemical SP method was used to detect the expression levels of Livin,Smac and Ki67 in 50 cases with epithelial ovarian cancer,20 cases with borderline ovarian tumor,20 cases with benign ovarian tumor and 20 cases with normal ovarian tissues.Results：The expression levels of Livin and Ki67 in epithelial ovarian cancer group were significantly higher than those in the other three groups（P0.01）.There was positive correlation between expression levels of Livin and Ki67 in ovarian tissues and histopathological grades,lymph node metastasis（P0.05）,but they were not related to histological types and stages.The expression level of Smac in epithelial ovarian cancer group was significantly lower than those in the other three groups（P0.01）.There was negative correlation between expression level of Smac in ovarian tissues and histopathological grades,lymph node metastasis（P0.05）,but they were not related to histological types and stages.Conclusion：Livin,Smac and Ki67 play important roles in the occurrence,differentiation and development of epithelial ovarian cancer,which may become new targets of epithelial ovarian cancer treatment.