120例重度外阴阴道假丝酵母菌病的远期疗效观察

Observation on the long-term efficacy of 120 cases with severe vulvovaginal candidiasis

目的:探讨重度外阴阴道假丝酵母菌病(VVC)合理规范有效的治疗方案。方法:选择120例重度VVC患者并随机分为A、B两组。A组60例,口服伊曲康唑200 mg/d,连续3天,同时阴道局部使用硝酸咪康唑阴道软胶囊1 200 mg,1次/3天,2日疗法。B组60例,A组方法+以后于月经干净后阴道局部使用硝酸咪康唑阴道软胶囊1 200 mg,连续用药3个月经周期。结果:A、B两组近期疗效显著,差异无统计学意义(P>0.05);远期疗效两组比较差异有统计学意义(P<0.05),B组复发率明显低于A组。结论:伊曲康唑和硝酸咪康唑联合用药优化治疗方案,能明显提高重度VVC的远期疗效,防止VVC的复发。

Objective：To explore a reasonable,normative and effective treatment protocol of severe vulvovaginal candidiasis（VVC）.Methods：120 patients with severe VVC were selected and divided into A group and B group randomly.60 patients in A group were treated with oral administration of itraconazole,200 mg per day for three days,at the same time,they were treated with vaginal administration of miconazole capsule（1 200 mg） every other two days for two times.60 patients in B group were treated with vaginal administration of miconazole capsule（1 200 mg） after menstruation for three menstrual cycles based on the treatment methods of A group.Results：The short-term efficacies in the two groups were remarkable,there was no significant difference between the two groups（P0.05）,but there was significant difference in long-term efficacy between the two groups（P0.05）.The recurrence rate in B group was lower than that in A group.Conclusion：Joint application of itraconazole and miconazole may improve the long-term efficacy of severe VVC obviously and prevent the recurrence of VVC.