2009-2010年浙江省人群甲型H1N1流感抗体水平调查分析

Evaluation of influenza A(H1N1) antibody level in Zhejiang,2009-2010

目的了解2009-2010年浙江省人群甲型H1N1流感抗体水平。方法每次调查在医院中非流感样病例就诊者、健康体检者和到血液中心的献血者共400人,并采集他们的血液样本5 ml/人,共调查5次。结果本研究共调查2 003人,甲型H1N1流感抗体阳性402人,阳性率20.07%。5次调查的抗体阳性率不同,随着时间的推移,抗体阳性率呈升高趋势。经统计学检验差异有统计学意义(χ2=69.072,P<0.01)。结论甲型H1N1流感是一种新型流感,人群的免疫力普遍较低。甲型H1N1流感疫苗的保护作用良好。但本次调查结果具有一定程度的偏倚,不能够完全地代表全人群的抗体阳性率水平。

Objective To analyze the influenza A（H1N1） antibody level in non-influenza-like outpatients.Methods A cluster random sampling method was used for specimen collection from November,2009 to March,2010.400 non-influenza-like outpatients were selected at each time.5.0 ml blood specimen was collected from each participant for the evaluation of influenza A（H1N1） antibody level.Results 2 003 subjects were included in the study.The prevalence of influenza A（H1N1） antibody was 20.07%（402/2 003） on average,with the trend of increase from the beginning to the end of sampling（the 1st batch：6.45% to 5th batch： 27%,P0.05）.There was no significant difference in the positive rates of anti-influenza A（H1N1） among the specimens collected from general hospitals,children hospitals and blood centers.17 participants had influenza A（H1N1） vaccination before and 4 of them were positive for the antibody testing.The low proportion of serum conversion was due to short time between vaccination and blood drawn.Conclusion The low proportion of anti-influenza A（H1N1） suggested the weak immunity of population against the 2009 novel influenza virus and the necessary of vaccination.