来曲唑等4种促排卵药物用于宫腔内人工授精的疗效比较

Effect Comparison of Four Ovarian Stimulation Protocols for Intrauterine Insemination

目的:比较来曲唑等4种促排卵药物用于宫腔内人工授精的疗效。方法:回顾分析南方医院生殖医学中心2006年1月至2010年6月采用自然周期(NC)和来曲唑(LE)、氯米芬(CC)、尿促性素(HMG)、尿促卵泡素(u-FSH)4种促排卵药物用于夫精宫腔内人工受精(IUI),共565个周期的临床资料进行比较分析。结果:5组临床妊娠率分别为4.1%、13.4%、8.7%、16.1%、13.8%,促排卵各组妊娠率均高于自然周期组(P均<0.05)。各促排卵组之间,妊娠率差异无统计学意义(P>0.05)。LE组优势卵泡数、排卵数及绒促性素(HCG)日子宫内膜厚度与NC组比较差异均无统计学意义(P>0.05)。结论:促排卵治疗增加IUI妊娠率。LE促排卵作用温和,妊娠率与低剂量HMG和u-FSH方案相当,用于IUI促排卵安全有效。

Objective：To compare the effects of four different ovarian stimulation protocols on intrauterine insemination（IUI）.Methods：A retrospective review was done to analyze the 565 IUI cycles from January 2006 to June 2010 at the Reproductive Center of Nanfang hospital.According to different ovulation stimulation protocols,patients were dedived into 5 groups：NC（natural cycle） group;LE（Letrozole） group;CC（Clomiphene citrate） group;HMG（Human menopausal gonadotrophin） group;u-FSH（urinary follicle stimulating hormone） group.Results：The pregnancy rates were 4.1%,13.4%,8.7%,16.1%,13.8% respectively for the five groups,also the pregnancy rate of every ovarian stimulation group was significantly higher than that of NC group（P〈0.05）,while no statistical differences of pregnancy rates were found among the four groups（P〈0.05）.The number of dominent follicles,the number of ruptured follicles and endometrium thickness at HCG day in LE group were no significant difference compared with those in NC group.Conclusions：Ovulation stimulation can increase the pregnancy rate in IUI cycle.Letrozole can provide mild ovarian stimulation and the similar pregnancy rate per cycle compared with low dose HMG or u-FSH,so it is safe and effective in IUI cycle.