重型甲型H1N1流感的早期预测指标

Early predictors of severe pandemic H1N1 influenza A

目的寻求重型甲型H1N1流感患者的早期预测指标。方法比较2009年6月~2010年1月南京地区经RT-PCR确诊的183例普通型和64例重型甲型H1N1流感患者的临床特点及实验室参数,分析重型患者的特征。结果重型外周血白细胞绝对数（6.13±4.06）×109/L,较普通型的（4.48±1.44）×109/L明显偏高（P〈0.01）;而同期淋巴细胞数（1.23±0.76）×109/L,较普通型（1.50±0.59）×109/L明显下降（P〈0.01）。结论除已知的重型甲型H1N1流感指征外,淋巴细胞比例和绝对计数下降可作为重型甲型H1N1患者的早期预测指标。

Objective To search for the early predictors of severe pandemic H1N1 influenza A.Methods The clinical and laboratory data of 183 common（group C） and 64 severe pandemic H1N1 influenza A patients（group S）,who were diagnosed by RT-PCR from June 2009 to January 2010 in Nanjing,China were analyzed.Results The absolute account of peripheral blood leukocytes in group S was （6.13±4.06）×109/L,which was significantly higher than（4.48±1.44）×109/L in group C（P0.01）.But the account of peripheral blood lymphocytes in group S was （1.23±0.76）×109/L,which was significantly lower than（1.50±0.59）×109/L in group C（P0.01）.Conclusion Besides the known indications of severe pandemic H1N1 influenza A,reduced proportion and absolute number of peripheral blood lymphocytes may serve as an early predictor of severe H1N1 influenza A.