原发性睾丸或阴茎非霍奇金淋巴瘤5例临床分析

Primary non-Hodgkin's lymphoma of the testis and penis:Clinical analysis of 5 cases

目的:探讨男性生殖系统非霍奇金淋巴瘤的临床诊断与治疗。方法:回顾性分析5例男性生殖系统原发性非霍奇金淋巴瘤的临床资料,其中原发于睾丸4例,原发于阴茎1例,并结合文献进行讨论。结果:5例患者均行手术治疗,病理类型均为非霍奇金淋巴瘤,术后3例行化疗,2例行放疗加化疗(原发于睾丸1例,原发于阴茎1例)。术后平均随访25个月,1例死亡,其余均存活。结论:男性生殖系统非霍奇金淋巴瘤临床症状不典型,多发生于老年,预后较差,确诊主要依靠组织病理学及免疫组化,治疗宜采取手术联合放疗及化疗。

Objective：To improve the clinical diagnosis and treatment of primary non-Hodgkin＇s lymphoma of male genitalia.Methods：We retrospectively reviewed the clinical data of 5 cases of primary non-Hodgkin＇s lymphoma of male genitalia,4 in the testis and 1 in the penis,we also analyzed the relevant literature and clinical significance of the disease.Results：All the 5 cases were treated by surgery and pathologically confirmed to be non-Hodgkin＇s lymphoma.Three of them received chemotherapy,and the other 2（1 in the testis and 1 in the penis） underwent both chemotherapy and radiotherapy after the operation.Follow-up averaged 25 months,during which 1 of the patients died and the other 4 survived.Conclusion：Primary non-Hodgkin＇s lymphoma of male genitalia is an uncommon disease with atypical clinical presentations and poor prognosis,which occurs mostly in elderly males.Definite diagnosis of the disease mainly depends on histopathology and immunohistochemistry.Surgery with multiagent chemotheraphy and radiotheraphy is advisable for its treatment.