低剂量辐射对不同岗位男性放射人员外周血T淋巴细胞亚群的影响

Effects of Low-dose Radiation on T Lymphocyte Subsets in Peripheral Blood of Different Positions of Male Radiation Doctor

目的：探讨低剂量辐射对不同岗位男性放射人员T淋巴细胞亚群水平的影响。方法：检测168例男性放射人员CD3＋T、CD3＋/CD4＋T、CD3＋/CD8＋T、CD4＋/CD45RA＋T、CD4＋/CD45RO＋T、CD8＋/CD45RA＋T、CD8＋/CD45RO＋T、CD8＋/CD28＋T、CD8＋/CD95＋T、CD8＋/HLA-DR＋T在淋巴细胞中的百分率,按工作岗位及工龄进行分组比较,以39名健康男性为对照。结果：CT组中,CD3＋/CD8＋T在~20和21~工龄组中的差异存在显著统计学意义（t=2.07,P〈0.05）;21~工龄组中,CD3＋/CD8＋T和CD8＋/CD45RO＋T在CT组和对照组中的差异存在显著统计学意义（t=-2.04,P〈0.05;t=-2.36,P〈0.05）。结论：低剂量电离辐射能引起CT机组20年以上工龄的男性放射人员CD3＋/CD8＋T的降低,应加强监控。

Objective To investigate effects of the ionizing radiation on T lymphocyte subsets in peripheral blood of different positions of male radiation personnel.Methods The CD3＋T,CD3＋/CD4＋T,CD3＋/CD8＋T,CD4＋/CD45RA＋T,CD4＋/CD45RO＋T,CD8＋/CD45RA＋T,CD8＋/CD45RO＋T,CD8＋/CD28＋T,CD8＋/CD95＋T,CD8＋/HLA-DR＋T percentage in the peripheral blood lymphocyte of 168 male radiation personnel were tested and compared by different jobs and working ages,with 39 healthy male controls.Results In CT group,CD3＋/CD8＋T between ~20 and 21~ working ages groups was statistically significant difference（t=-2.07,P0.05,t=-2.36,P0.05）.In 21~ working ages group,CD3＋/CD8＋T and CD8＋/CD45RO＋T between CT group and control group were both significant different（t=-2.04,P0.05,t=-2.36,P0.05）.Conclusion Reduce of CD3＋/CD8＋T lymphocyte subset was mainly caused by low-dose ionizing radiation in male radiation doctor who worked in CT position longer than 20 years.We should pay attention to that.