不稳定型心绞痛患者血清Hcy和sFas的水平及相关分析

Study on the Relationship Between Serum Hcy and Soluble Fas Levels in Patients with Unstable Angina Pectoris

目的:探讨不稳定型心绞痛(unstable angina pectoris,UAP)患者血清Hcy水平的变化和可溶性Fas(sFas)水平的相关性。方法:应用酶联免疫吸附法(ELISA)对60例UAP患者进行了血清Hcy和血清sFas检测并与40例正常健康人做比较。结果:危险分层为Ⅱ、Ⅲ级的UAP患者血清Hcy与sFas水平非常显著地高于正常对照组(P<0.01);组间比较,危险分级Ⅱ、Ⅲ级UAP患者血清Hcy与sFas水平明显高于危险分级Ⅰ级组;UAP患者血清Hcy水平与sFas水平呈明显正相关(r=0.586,P<0.01)。结论:高水平的血清Hcy和sFas与UAP有关,可能通过细胞凋亡和炎症反应途径参与冠状动脉粥样硬化斑块的发生发展。

Objective To study the relationship between changes of serum Hcy and soluble Fas（sFas） levels in patients with unstable angina pectoris.Methods Serum Hcy and sFas（with ELISA） levels were measured in 60 patients with UAP（every stage of Ⅰ,Ⅱ,Ⅲ： 20 patients） and 40 controls.Results Levels of serum Hcy and sFas were significantly higher in the patients of Ⅱ,Ⅲ stage of UAP than those in controls（P0.01）,in the same group,the levels of serum Hcy and sFas were obviously higher in the Ⅱ,Ⅲ stage of UAP than that in I stage of UAP,These two variables were significantly positively correlated（r=0.586,P0.01）.Conclusion High levels of Hcy and sFas have relationship with UAP.They may be contribute to the development of atherosclerotic plaque by cell apoptosis and inflammatory response.