COPD患者血脂代谢水平和hs-CRP水平关系的分析

Analysis of Relationship Between Blood Lipid Metabolism Levels and hs-CRP Levels in Patients with Chronic Obstructive Pulmonary Disease

目的:进行慢性阻塞性肺病(COPD)患者血脂代谢水平和hs-CRP水平关系的分析。方法:利用生化法测定了96例COPD患者血脂代谢水平,免疫比浊法测定了血清hs-CRP水平,并与68例正常对照组进行了比较。结果:96例COPD患者的血浆TC、TG、HDL-C、LDL-C和Lp(a)较之68例正常对照组明显降低,TC和LDL-C水平无明显差异(P>0.05),HDL-C水平具有明显差异(P<0.05),而TG和Lp(a)水平具有非常明显的差异(P<0.01)。血浆hs-CRP水平明显升高,具有非常明显的差异(P<0.01),并且COPD患者中的血脂代谢水平和hs-CRP水平存在着直接的相关性。结论:COPD患者血脂水平和hs-CRP水平相关性的分析,有助于了解其发病机制。

Objective To study the relationship between blood lipid metabolism levels and hs-CRP levels in the patients with chronic obstructive pulmonary disease.Methods The levels of plasma blood lipid（with biochemistry） and serum hs-CRP（with high-sensitive immunoturbidimetry） were determined in 96 patients with chronic obstructive pulmonary disease as well as 68 normal controls.Results The plasma blood lipid levels in 96 patients with chronic obstructive pulmonary disease were significantly lower than those in 68 controls,plasma TC and LDL-C levels were not much difference（P0.05）,plasma HDL-C level was significantly difference（P0.05）,but TG and Lp（a） levels were very prominently difference（P0.01）.And the plasma hs-CRP level was significantly increased also（P0.01）.The close relationship was between blood lipid and hs-CRP levels.Conclusion The study of relationship between blood lipid levels and hs-CRP levels in patients with COPD was helpful for understend the disease process as well as possible mechanisms.