调环酸钙安全性初步评价

Preliminary evaluation on the security of prohexadione-calcium

【目的】评价调环酸钙原药的急性毒性,为安全使用调环酸钙提供毒理学依据。【方法】按照我国现行《农药登记毒理学试验方法》(GB15670-1995)规定的方法,以SD大鼠为对象,采用一次最大剂量法,对调环酸钙原药进行急性经口、经皮毒性试验。【结果】调环酸钙原药对SD大鼠的急性经口半数致死量(LD50)>5000mg/kg·BW,经皮LD50>2000mg/kg·BW。【结论】调环酸钙对大鼠的急性经口、经皮毒性均属于低毒性,符合绿色农业生产的要求。

【Objective】The objective of the present study was to test the acute toxicity of the raw pesticides of prohexadione-calcium, and to provide toxicological basis for using proexhadione calcium safely. 【Method】The tests of acute oral and percutaneous toxicity were undertaken based on the Chinese standards （GB 15670-1995） of Toxicological Test Methods of Pesticides for Registration. 【Result】The acute oral toxicity LD50 of proexhadione calcium on SD rats was over 5000 mg/kg·BW, and the percutaneous toxicity was over 2000 mg/kg·BW. 【Conclusion】The acute oral, percutaneous toxicity of percutaneous toxicity on rats is low, which is safe for human beings and domestic animals.