2型糖尿病肾病患者炎性反应相关因子检测与分析

Detection and analysis for inflammation-associated factors in patients with type 2 diabetic nephropathy

目的探讨糖尿病肾病患者的血清C反应蛋白、可溶性白细胞介素-2受体(sIL-2R)、白细胞介素-6(IL-6)和血清转化生长因子-β1(IGF-β1)水平的变化在糖尿病肾病发生、发展中的作用。方法将98例糖尿病肾病患者24 h尿微量清蛋白排泄率分为:无蛋白尿组(UAER<20 g/min,n=32)、微量蛋白尿组(UAER<290 g/min,n=35)和大量蛋白尿组(UAER>200 g/min,n=31)。观察各组患者CRP、slL-2RI、L-6和TGF-β1水平的变化,并与健康对照组(n=32)进行比较。结果无蛋白尿组、微量蛋白尿组及大量蛋白尿组的CRP、slL-2R、IL-6及TGF-β1水平均明显高于健康对照组(P<0.01);微量蛋白尿组的CRP、slL-2RI、L-6及TGF-β1水平明显高于无蛋白尿组(P<0.05);大量蛋白尿组的CRP、slL-2RI、L-6及TGF-β1水平明显高于微量蛋白尿组(P<0.01)。结论早期检测血清CRP、slL-2RI、L-6及TGF-β1水平的变化可以作为临床观察糖尿病肾病病情及判断糖尿病预后的参考指标。

Objective To investigate the significance of serum level changes of C-reactive protein（CRP）,interleukin-2receptor（sIL-2R）,interleukin-6（IL-6）and transforming growth factor-beta 1（TGF-β1）in the patients with diabetic nephropathy.Methods 98 patients with diabetic nephropathy were divided in to three groups according to the excretion rate of urinary microalbumin in 24 hours.Group A：without alblminuria（UAER20 g/min,n=32）,Group B：microalbumin（UAER200 g/min,n=35）,Group C：high-grade proteinuria（UAER200 g/min,n=31）.The serum level changes of CRP,sIL-2R,IL-6 and TGF-β1 from the three groups were observed and compared with 32 controls.Results Serum levels of CRP,sIL-2R,IL-6 and TGF-β1 in the patients with diabetic nephropathy were significantly higher than those in controls（P0.01）.Serum levels of CRP,sIL-2R,IL-6 and TGF-β1 in group B were significantly higher than those in group A（P0.05）.Serum levels of CRP,sIL-2R,IL-6 and TGF-β1 in group C were significantly higher than those in group B（P0.01）.Conclusion Early detection of serum level changes of CRP,sIL-2R,IL-6 and TGF-β1 might be helpful for the condition observation and prognostic judgment of patients with diabetic nephropathy.