继发性乳糖不耐受症与轮状病毒性肠炎的关系分析

The correlation analysis on the rotavirus enteritis and secondary lactose intolerance

目的探讨轮状病毒性肠炎与继发性乳糖不耐受的关系。方法对200例轮状病毒性肠炎患儿用醋酸铅加氢氧化氨法检测粪乳糖、pH值。粪乳糖大于或等于++,pH<5.5为乳糖不耐受症,将200例患儿分为治疗Ⅰ组及治疗Ⅱ组,粪乳糖阴性为对照组。结果 200例轮状病毒性肠炎中粪乳糖大于或等于++,pH<5.5,138例,其中年龄小于或等于6个月32例,≤1岁68例,≤2岁36例,≤3岁2例。治疗Ⅰ组及治疗Ⅱ组临床症状与对照组比较差异有统计学意义(P<0.01),治疗Ⅰ组与对照组疗效比较差异无统计学意义(P>0.05),治疗Ⅱ组与对照组疗效比较差异有统计学意义(P<0.01)。结论轮状病毒性肠炎容易导致继发乳糖不耐受症,且年龄越小,越容易发生继发性乳糖不耐受症,去乳糖饮食治疗轮状病毒性肠炎继发性乳糖不耐受症疗效显著,对轮状病毒性肠炎患儿应检测粪乳糖及pH,及早发现继发性乳糖不耐受症。

Objective To investigate the relationship between rotavirus enteritis and secondary lactose intolerance.Methods We examined feces lactose,PH in 200 rotavirus enteritis patients by the measure of lead acetate with ammonia hydroxide,feces lactose≥＋＋ and PH5.5 were diagnosed secondary lactose intolerance.These patients were divided into treatment groupⅠand groupⅡ.Patients of feces lactose＋＋,PH5.5 were chosen as the control group.Results 138 of the 200 cases were diagnosed secondary lactose intolerance,age≤6-month 32 cases,≤1-year 68 cases,≤2-year 36 cases,≤3-year 2 cases.There was a significant difference in clinical symptoms between group Ⅰor groupⅡand the control group（P0.01）.There was no difference in therapeutic effect of disease between group Ⅰand the control group（P0.05）,There was a significant difference in therapeutic effect of disease between the group Ⅱ and the control group（P0.01）.Conclusion There is a higher incidence of secondary lactose intolerance in the children with rotavirus enteritis.The younger the infants are,the higher incidence of secondary lactose intolerance would be.Non-lactose diet is an effective therapy,it is suggested that every child with rotavirus enteritis should be screened for secondary lactose and treated with non-lactose diet,when he or she is identified to have secondary lactose.