降钙素原在感染性发热诊断中的意义

Significance of procalcitonin in the diagnosis of infectious fever

目的分析感染性发热患者中细菌感染和病毒感染血清降钙素原(PCT)水平的差别,探讨血清PCT在感染性发热诊断中的意义。方法采用半定量固相免疫测定法测定48例细菌感染性发热患者、40例病毒感染性发热患者以及30例健康对照组血清中的PCT,将检测结果分成4个水平,PCT<0.5 ng/mL,0.5 ng/mL≤PCT<2.0 ng/mL,2.0 ng/mL≤PCT<10.0 ng/mL和PCT≥10.0 ng/mL,分析PCT水平与细菌病毒感染之间的关系。以PCT≥0.5 ng/mL为阳性诊断标准。结果细菌感染组患者血清PCT水平高于病毒感染组和对照组,差异有统计学意义(P≤0.05),病毒感染组与对照组之间差异无统计学意义(P>0.05)。结论检测PCT能有效地鉴别细菌性和非细菌性感染性发热,有利于早期正确治疗。

Objective To analyze the different procalcitonin（PCT）levels in serum between the infectious fever of bacterial and viral in order to explore the significance of PCT in the diagnosis of infectious fever.Methods The serum PCT was measured by semi-quantitative solid phase immuno-assay in 48 patients with infection of bacteria,40 patients with infection of virus and 30 healthy people.PCT was tested according to 4 levels which were PCT0.5 ng/mL,0.5 ng/mL≤ PCT 2.0 ng/mL,2.0 ng/mL≤ PCT 10.0 ng/mL and PCT≥10.0 ng/mL.And the relationship between the serum level of PCT and bacterial infection or viral infection was analyzed,PCT≥0.5 ng/mL was taken as the criterion.Results The PCT level of patients with bacterial infection was significantly higher than that of patients with viral infection and healthy group（P≤0.05）,but there was no difference between the PCT level of patients with viral infection and that of healthy group（P0.05）.Conclusion It shows that testing PCT can effectively identify bacterial and non-bacterial infectious fever.Therefore,it could be applicable for early treatment.