新疆汉、维吾尔族食管鳞癌患者血清VEGF、EGFR、ES、HER2、NF-kBp的表达水平及其临床病理学意义

Expression and clinicopathological significance of serum VEGF,EGFR,ES,HER2,NF-kBp in Uygur and Han's esophageal cancer

目的探讨新疆汉族、维吾尔族食管鳞癌患者血清人血管内皮细胞生长因子(vascular endothelialgrowth factor,VEGF)、人表皮生长因子受体(epithelial growth factor receptor,EGFR)、人内皮抑制素(endostatin,ES)、人表皮生长因子受体2(human epithelial growth factor receptor-2)、人核转录因子-kB亚基p65亲和肽(NF-kBp)表达水平的差异及临床病理学意义。方法采用ELISA法测定40例局部晚期食管鳞癌患者(食管鳞癌组中汉族和维吾尔族各20例)及20名健康人(正常对照组)血清VEGF、EGFR、ES、HER2、NF-kBp的表达水平。结果 (1)食管鳞癌组血清VEGF、EGFR、ES的表达水平均高于正常对照组(P<0.05);(2)汉族食管癌患者血清VEGF、ES的表达水平明显高于维吾尔族食管癌患者(P<0.05);(3)血清VEGF、EGFR、ES、HER2、NF-kBp的表达水平与性别、年龄、病理分级及临床分期等因素无关。结论检测部分血清肿瘤标记物对食管癌患者的诊断具有一定临床的意义;部分血清肿瘤标记物在新疆汉族和维吾尔族中的表达具有一定的差异。

Objective To study the expression difference and the clinicopathological significance of serum VEGF,EGFR,ES,HER2,NF-kBp in patients with local advanced esophageal squamous cell carcinoma.Methods The levels of serum VEGF,EGFR,ES,HER2,NF-kBp in 20 cases and 20 healthy controls were measured by ELISA.Results Serum VEGF,EGFR,ES levels of cases were higher than the normal controls as follows： VEGF（182.24±28.93） ng/L and（102.04±8.13） ng/L,EGFR（1.07±1.48） ng/L and（0.62±0.03） ng/L,ES（18.23±3.17） ng/L and（7.83±0.32） ng/L（P0.05）,serum VEGF,ES levels in Han population were obviously higher than Uygur cases as follows： VEGF（258.48±39.38） ng/L and（106.00±28.76） ng/L（P0.05）;ES（27.88±43.22） ng/L and（8.59±263） ng/L（P0.05）.The levels of serum VEGF,EGFR,ES,HER2,NF-kBp levels were not associated with gender,age,pathologic stage and the clinical stages of the patients.Conclusion Testing some esophageal cancer markers in patients had somewhat clinical diagnosis significance,some serum markers expression were different in Uygur and Han patients with esophagus carcinoma in Xinjiang.