葎草花粉过敏性鼻炎与HLA-DQA1基因的相关性探讨

Linkage of allergic rhinitis with HLA-DQA1 gene

目的研究沈阳地区草花粉过敏变应性鼻炎患者HLA-DQA1基因与草花粉过敏易感性的关系。方法用聚合酶链反应-序列特异性引物技术(PCR-SSP),检测HLA-DQA1基因在74例以草花粉过敏为主的AR(AllergieRhinit’s,AR)患者及54例对照组间的分布,并统计分析了二者间的分布差异。结果 74例变应性鼻炎患者疾病组HLA-DQA1*0104基因发生率(37.8%)明显高于对照组(0%),P<0.01有显著性差异。而疾病组HLA-DQA1*0501基因发生率(3.38%)明显低于对照组(24.07%),(P<0.01)有显著性差异。结论提示HLA-DQA1*0104可能是AR的易感基因,HLA-DQA1*0501可能是AR的抗性基因。

Objective To investigate whether susceptibility to allergic rhinitis associated with HLA-DQA1 alleles.Methods Using PCR-SSP（sequence-specific primer polymerase chain reaction）,we tested the frequency distribution of HLA-DQA1 alleles in 74 patients with allergic rhinitis（AR） and 54 healthy controls from Shenyang China.Results The frequence of HLA-DQA1＊0104 was higher in AR than in controls（37.8% vs 0%,P0.01）;The frequence of HLA-DQA1＊0501 was lower in AR than in controls（3.38% vs 24.07%,P0.01）.Conclusion HLA-DQA1＊0104 might be predisposing genes of AR;HLA-DQA1＊0501 might confer protection against AR.