肾损伤分子-1在创伤导致急性肾损伤早期诊断中的意义

Monitoring Urinary Kidney Injury Molecule-1 in Acute Kidney Injury after Trauma

目的观察肾损伤分子-1(Kidney Injury Molecule-1,KIM-1)在急性肾损伤(acute kidney injury,AKI)患者尿液中的变化,探讨在早期诊断中的意义。方法收集骨科和ICU住院的创伤患者,采用ELISA方法检测血或尿中KIM-1含量,采用速率散射比浊发检测尿白蛋白(albumin,Alb)、α1-微球蛋白(α1-microglobulin,α1-MG)。结果与健康对照组相比,1期、2期、3期AKI组,尿KIM-1均明显升高(P<0.05),其中2期、3期AKI组尿KIM-1明显高于1期AKI(P<0.05),尿KIM-1与α1-MG正相关。结论 AKI发生时,检测尿KIM-1有助于AKI的早期诊断和反应肾小管损伤。

Objective To investigate the significance of Kidney Injury Molecule1（KIM-1） changes in urine in patients with acute kidney injury（AKI）.Methods Urine samples were collected from 103 patients with trauma.Urinary KIM-1 was assayed by ELISA.Urinary albumin,α1-microglobulin were assessed by rate nephelometry.The correlation between KIM-1 and α1-microglobulin in urine was analyzed.Results Urinary KIM-1 increased significantly in patients with stage 1,2,3 AKI,as compared with that in end stage renal disease（ESRD） and healthy volunteers（P0.05）.Urinary KIM-1 was highest in phase 2 patients that phase 1,3 AKI（P0.05）.Urinary KIM-1 was correlated with urnary α1-microglobulin.Conclusion Urinary KIM-1 is a useful marker for the early diagnosis of AKI and facilitating the rapid and early detection of kidney injury in clinical studies.