视神经视网膜疾病的神经保护
摘要
恢复和保存患者的视力是眼科医师的宗旨。视神经视网膜疾病是眼科主要且难治性致盲性疾病,主要原因是这类疾病是以视网膜的神经细胞死亡为特征的,而视网膜属于中枢神经系统的一部分,神经细胞一旦死亡即难以再生和修复,因而这类疾病成为难治性的致盲疾病。
出处
《中华临床医师杂志(电子版)》
CAS
2011年第5期15-18,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
国家自然科学基金(30872835)
北京市自然科学基金(7092107)
参考文献28
-
1Miller NR.Optic nerve protection,regeneration,and repair in the 21st century:LVIII Edward Jackson Memorial lecture.Am J Ophthalmol,2001,132:811-818.
-
2Dahlmann-Noor AH,Vijay S,Limb GA,et al.Strategies for optic nerve rescue and regeneration in glaucoma and other optic neuropathies.Drug Discov Today,2010,15:287-299.
-
3Curcio CA,Medeiros NE,Millican CL.Photoreceptor loss in agerelated macular degeneration.Invest Ophthalmol Vis Sci,1996,37:1236-1249.
-
4Yang L,Bula D,Arroyo JG,et al.Preventing retinal detachmentassociated photoreceptor cell loss in Bax-deficient mice.Invest Ophthalmol Vis Sci,2004,45:648-654.
-
5Parrilla-Reverter G,Agudo M,Sobrado-Calvo P,et al.Effects of different neurotrophic factors on the survival of retinal ganglion cells after a complete intraorbital nerve crush injury:a quantitative in vivo study.Exp Eye Res,2009,89:32-41.
-
6Martinou JC,Dubois-Dauphin M,Staple JK,et al.Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia.Neuron,1994,13:1017-1030.
-
7Cenni MC,Bonfanti L,Martinou JC,et al.Long-term survival of retinal ganglion cells following optic nerve section in adult bcl-2 transgenic mice.Eur J Neurosci,1996,8:1735-1745.
-
8Liu X,Rasmussen CA,Gabelt BT,et al.Gene therapy targeting glaucoma:where are we? Surv Ophthalmol,2009,54:472-486.
-
9Sun X,Zhou H,Luo X,et al.Neuroprotection of brain-derived neurotrophic factor against hypoxic injury in vitro requires activation of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase.Int J Dev Neurosci,2008,26:363-370.
-
10Mansour-Robaey S,Clarke DB,Wang YC,et al.Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells.Proc Natl Acad Sci U S A,1994,91:1632-1636.
二级参考文献27
-
1Rivoha C, Sharon D, DeAnge MM, et al. Retinitis pigmentosa and allied diseases numerous diseases, genes, and inheritance patterns. Hum Mol Genet, 2002,11 : 1219-1227.
-
2Manji HK, Moore GJ, Chen G. Lithium at 50: Have the neuroprotective effects of this unique cation been overlooked? Biol Psychiatry, 1999, 46: 929-940.
-
3Huang X, Wu DY, Chen G, et al. Support of retinal ganglion cell survival and axon regeneration by lithium through a Bel-2- dependent mechanism. Invest Ophthalmol Vis Sci, 2003, 44: 347-354.
-
4Brunello N. Mood stabilizers: protecting the mood...protecting the brain. J Affective Disorders, 2004, 79 Suppl 1 :S15-20.
-
5Fauser S, Luberichs J, Schuttauf F. Genetic animal models for retinal degeneration. Surv Ophthalmol, 2002, 47: 357-367.
-
6Chang B, Hawes NL, Hurd RE, et al. Retinal degeneration mutants in the mouse. Vision Research, 2002, 42 : 517-525.
-
7Yang L, Bula D, Arroyo JG, et al. Preventing retinal detachmentassociated photoreceptor cell loss in Bax-deficient mice. Invest Ophthalmol Vis Sci, 2004, 45 : 648-654.
-
8Chang GQ, Hao Y, Wong F. Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Neuron, 1993, 11:595-605.
-
9Portera-Cailliau C, Sung CH, Nathans J, et al. Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Proc Nail Acad Sci, 1994, 91 : 974-978.
-
10Cayouette M, Smith SB, Becerra SP, et al. Pigment epithehumderived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis, 1999, 6: 523- 532.
共引文献5
-
1周朋义,彭广华.视网膜色素变性治疗的研究进展[J].眼科新进展,2012,32(5):493-496. 被引量:14
-
2蓝海光,玉远林,李国梁.原发性视网膜色素变性的诊治体会[J].吉林医学,2013,34(6):1103-1103. 被引量:2
-
3杨臣,王希英,方振兴.火焰原子吸收光谱法测定五大连池重碳酸矿泉水中的7种元素[J].光谱实验室,2013,30(2):712-716. 被引量:6
-
4祁晓君,张洁,冯炜,刘晓坤,赵平.丙戊酸钠在大鼠视神经损伤再生中的作用研究[J].中华眼外伤职业眼病杂志,2014,36(9):641-646. 被引量:2
-
5龚海军,郭萍.隐匿性视神经损伤的护理探讨[J].世界最新医学信息文摘,2016,0(32):267-267. 被引量:1
-
1刘伟国,杨小锋,高峰,姜秀意,童建忻.低强度微波辐射对大鼠神经细胞死亡率影响的实验研究[J].浙江创伤外科,2001,6(3):141-142.
-
2刘婉莹,张卯年,鞠躬,黄厚斌.大鼠视神经切开减压术后超微结构的变化[J].解放军医学杂志,2006,31(7):668-669. 被引量:1
-
3王笃玉.深层巩膜咬切术治疗青光眼临床体会[J].济宁医学院学报,2004,27(2):24-24. 被引量:1
-
4胡博杰,刘慧,王勇,刘巨平,邵彦,李筱荣.表面麻醉在23G微创玻璃体切割手术中的应用[J].中华眼底病杂志,2011,27(2):181-182. 被引量:3
-
5中华健康快车基金会举办“全国爱眼日”活动[J].中华眼科杂志,2011,47(7):668-668.
-
6谢汉平,阴正勤,王一,郑汉.对眼科继续教育短期学习班的探讨[J].现代医药卫生,2002,18(6):541-542.
-
7王敏,叶静.在经济欠发达地区开展白内障手术的体会[J].实用防盲技术,2006,1(4):23-23.
-
8贾亮,尹东芳.鼻内窥镜在眼科手术中的应用进展[J].中国急救复苏与灾害医学杂志,2012,7(5):471-473. 被引量:3
-
9中山大学中山眼科中心“小儿白内障之家”成立[J].中华眼科杂志,2011,47(12):1101-1101.
-
10中山大学中山眼科中心“小儿白内障之家”成立[J].中华眼科杂志,2011,47(11):1018-1018.