辛伐他汀治疗煤工尘肺肺动脉高压患者的临床观察

Clinical study on simvastatin treatment of pulmonary hypertension in patients with coal worker＇s pneumoconiosis

目的探讨辛伐他汀治疗煤工尘肺肺动脉高压的疗效。方法选择煤工尘肺肺动脉高压患者96例，随机分为治疗组（48例）和对照组（48例）。对照组口服华法林2．5mg，每天1次，共4个月；治疗组口服辛伐他汀20mg，每晚1次，共4个月。治疗前后进行6min步行试验及以超声心动图测肺动脉压力。结果治疗组治疗后6min步行距离为（258±26）m，与治疗前[（225±19）m]及对照组治疗后[（240±20）m]比较，差异均有统计学意义（P〈0．05，P〈0．01）。治疗组治疗后肺动脉压力为（36±3）mm№，较治疗前[（41±9）mmHg]及对照组治疗后[（39±5）mmHg]明显降低，差异有统计学意义（P〈0．05）。结论辛伐他汀能改善煤工尘肺肺动脉高压，疗效确切。

Objective To observe simvastatin treatment of pulmonary hypertension in patients with coal workers pneumoconiosis （CWP）. Methods 96 CWP patients with pulmonary hypertension were randomly divided into treatment and control groups. The control group was treated with 2.5 mg warfarin, once a day for four months; the treatment group was treated with 20 mg simvastatin, taken in evening, for 4 months. 6 min walking distance （6MWD） test and inspection pulmonary artery pressure were measured by echocardiography before and after treatment. Results In the treatment group, the 6MWD were （258±26）m after treatment and （225±19）m before treatment, respectively. Compared with control group, pulmonary artery pressure was （41±9）mm Hg in the treatment group before treatment, （36±3）mm Hg in the treatment group after treatment, and（39±5 ）mm Hg in control group, respectively, the diffrence was statistically significant（P〈 0.05）. Conclusions Simvastatin can improve pulmonary hypertension in coal workers pneumoconiosis, and shows a definite curative effect.