171例老年鼻咽癌临床及预后因素分析

Prognostic Factors of Elderly Nasopharyngeal Carcinoma: A Report of 171 Cases

目的分析老年鼻咽癌的临床特点,探讨影响其预后的因素。方法对171例老年鼻咽癌患者的临床特点、治疗方法、生存期及预后因素进行单因素和多因素分析。结果 1、3、5年总生存率和肿瘤特异性生存率分别为78%、55%、40%和84%、63%、52%。单因素分析显示性别、T分期、N分期、临床分期、颅底骨侵犯、颅神经损伤、放疗中断天数对总生存率和肿瘤特异性生存率的影响有显著差异。多因素分析显示临床分期、放疗中断天数是影响老年鼻咽癌患者生存的独立预后因素(P<0.05)。结论临床分期和放疗中断天数对老年鼻咽癌预后有影响;老年鼻咽癌患者非肿瘤性死亡的概率较大。

Objective To analyze the prognosis factors affecting long-term results in elderly nasopharyngeal carcinoma.Methods One hundred and seventy-one nasopharyngeal carcinoma with clinical data with age equal to or greater than 60 years were observed at our hospital.Prognosis factors were studied by univariate and multivariate analyses for survival.Results The 1-year,3-year,5-year overall survival rates and cancer-specific survival rates of the 171 elderly nasopharyngeal carcinoma patients were 78%,55%,40% and 84%,63%,52%,respectively.Gender,clinical stage,T stage,N stage,violations of the skull base bone,cranial nerve injury and radiotherapy interruption days were significant prognostic factors of survival rates by single-factor analysis（P0.05）.Multivariate analysis showed that clinical stage and radiotherapy interruption days were also independent predictors.Conclusion Clinical stage and radiotherapy interruption days can affect the prognosis of aged nasopharyngeal carcinoma patients.Elderly patients have a great risk of death from non-malignant diseases.