老年人胃癌的浸润深度和术后化疗对预后的影响

Effects of Invasion Depth of Gastric Cancer and Postoperative Chemotherapy on Prognosis of Elderly Patients

目的探讨接受手术治疗的老年人胃癌临床病理因素与预后的关系。方法回顾性研究本院2002年1月至2005年12月胃癌手术患者,记录患者的年龄、性别、肿瘤位置、肿瘤大小、共存病(高血压及心脏病)、手术根治程度、胃切除范围、病理类型(WHO)、TNM分期、术后化疗情况,建立数据库。结果老年组中位生存时间为29月(平均44月),明显低于中年组(78月,P=0.001)和青年组(72月,P=0.009);老年患者原发肿瘤以T3/T4为主;较少的患者接受联合脏器切除;更多合并高血压及心脏病,而较少患者接受术后化疗。结论老年人胃癌手术患者原发灶的侵犯深度、术后较少接受化疗与预后差有关。

Objective To define the relationship between clinicopathological factors and the prognosis of the elderly gastric cancer patients with surgical therapy.Methods A retrospective database of the gastric cancer patients undergoing surgical resection from January 2002 to December 2005 was collected.Clinicopathological characteristics were analyzed,and these including age,gender,location and size of tumor,morbidities（hypertension and heart disease）,type of radical or palliative surgery,volume of gastric resection,WHO pathological type,TNM stage,and postoperative chemotherapy.Results The median survival time of elderly patients group（more than 70 years old） is 44 months,which is shorter than other groups with the middle age group（range,41~69 year,P=0.001） as 78 months and the young group（less than 40 year,P=0.009） as 72 months.In the elderly patients,the primary lesion of gastric cancer mostly presented with T3/T4,but combined resection of involved organs less performed,more with morbidities such as hypertension and heart disease,but postoperative chemotherapy less received.Conclusion Progressive invasion depth of gastric cancer and not receiving postoperative chemotherapy correlated with poor prognosis.