草分支杆菌注射液联合苄星青霉素治疗早期梅毒的疗效分析

Efficacy analysis of Mycobacterium phlei combined with benzathine penicillin in the treatment of early syphilis

目的:探讨草分支杆菌注射液联合苄星青霉素在早期梅毒治疗中的作用。方法:将80例早期梅毒患者分为治疗组(草分支杆菌注射液联合苄星青霉素)和对照组(单用苄星青霉素),观察时间6个月。结果:治疗3、6个月时治疗组快速血浆反应素试验(RPR)几何平均滴度低于对照组(P<0.05),治疗6个月治疗组RPR阴转率为40%,对照组为21.2%,两者差异有统计学意义(P<0.05)。结论:草分支杆菌注射液辅助治疗早期梅毒可以增强苄星青霉素驱梅的疗效。

AIM ： To investigate the effects of Mycobacterium Phlei combined with benzathine penicillin in the treatment of early syphilis. METHODS ： Eighty cases of early syphilis were divided into treatment group（Mycobacterium phlei combined with Benzathine penicillin） and control group（benzathine penicillin alone）,all the patients were observed for 6 months. RESULTS ：The geometric mean titers of rapid plasma reagin test（RPR） in the treatment group at the 3th and 6th months were lower than those in the control group（P 0.05）.The RPR negative conversion rate was 40% after 6 months in treatment group,while 21.2% in the control group,the difference was significant（P 0.05）. CONCLUSION ： Mycobacterium Phlei can enhance the efficacy of benzathine penicillin in the treatment of early syphilis.