有机酸抑菌分子机理研究进展

Advances in Antimicrobial Molecular Mechanism of Organic Acids

有机酸作为一种可有效抑制畜禽体内病原微生物增殖的饲用生长促进剂,正日益受到关注。不同有机酸抑菌机理不尽相同。笔者综述了有机酸分子水平抑菌机理研究的最新进展,包括基于能量竞争、透化细菌外膜、提高胞内渗透压、抑制生物大分子合成、诱导宿主产生抗菌肽等5种作用机制;认为细菌胞内酸根离子的聚集是有机酸抑菌作用的重要决定因素,细菌胞内外pH梯度及胞外酸根离子浓度又是影响胞内酸根离子聚集的主要因素。

Organic acids,as growth promoter,have antimicrobial effects on animals,through different mechanisms.In this review,five possible mechanisms of organic acids are discussed including： energy competition permeabilizing through outer membrane,increase of cellular osmolarity,inhibition of macromolecule synthesis and induction of antimicrobial peptide in host cell,at levels of molecular mechanism,respectively.This review concludes that,the intracellular accumulation of anions of organic acid is a primary contributor to antimicrobial effects,which can be influenced by differences or shifts between intracellular and extracellular concentration of pH and anion concentration of extracellular acids.