人工肌腱材料与运动性肌腱损伤的修复

Artificial tendon materials in repair of sports-induced tendon injury

背景:运动或疾病导致肌腱损伤,若未予以及时修复常会导致肢体功能障碍,植入人工肌腱后,可形成类似生物腱的组织。目的:分析运动导致肌腱损伤的原理,以及人工肌腱在运动导致的肌腱损伤的应用价值。方法:作者检索1990/2010 PubMed数据库及中国知网数据库检索与人工肌腱在运动导致的肌腱损伤的应用的相关研究。结果与结论:过度运动可导致肌腱断裂损伤,人工肌腱由细胞、生长因子及可降解生物材料构成,在植入人体后,能恢复患者肌腱原有的生物学特性,部分人工肌腱甚至可以增殖和合成胶原。随人工肌腱支架材料的降解,患者体内将逐渐形成在功能和形态上与正常肌腱相似的新生肌腱组织。且随组织工程学的发展,将出现更多应用于运动导致的肌腱损伤、断裂等疾病治疗的新型人工肌腱。

BACKGROUND：Sports-or disease-induced tendon injury often leads to limb dysfunction if not be repaired in time,following an implantation of artificial tendon,the tissue can be formed similar to biological tendon.OBJECTIVE：To analyze the principle of sports tendon injury and application value of artificial tendon in sports tendon injuries.METHODS：PubMed database and CNKI database were searched from 1990 to 2010 for articles about the application of artificial tendon in sports tendon injury.RESULTS AND CONCLUSION：Excessive exercise can lead to tendon injuries,artificial tendon comprises cells,growth factors,and biodegradable materials.Once implanted into human body,artificial tendon can restore the original biological characteristics of tendon,some tendons can even proliferate and synthesize collagen.With the artificial tendon scaffold degrades,a new tendon tissue will be gradually form in the patient＇s body with similar function and morphology to normal tendon.More new artificial tendons for treatment of sports tendon injury and fracture will appear with the development of tissue engineering.