人用流感禽流感联合疫苗的研究

Human/avian influenza conjugated vaccines for human use

目的了解人流感疫苗和H5N1禽流感疫苗联合后的安全性和疫苗之间产生抗体的相互干扰现象。方法制成禽流感单价疫苗、人流感3价疫苗和流感禽流感联合4价疫苗,免疫家兔,测定中和抗体和血凝抑制抗体,并接种小鼠和豚鼠,观察毒性反应和过敏反应。结果人流感疫苗和禽流感疫苗的联合,基本上没有发生疫苗对各自抗体产生的干扰;接种动物无毒性反应。结论 2种疫苗的联合是完全可能的。

In this study,the safety of the influenza vaccine conjugated with H5N1 avian influenza vaccine were investigated,and the cross-reaction between the two vaccines were tested.The monovalent-,tervalent-and quadrivalent-influenza vaccines and avian influenza were prepared,rabbits were immunized subsequently,and neutralizing antibodies and haemagglutination inhibition antibodies were further measured.Additionally,these vaccines were used to inoculate mouse and guinea pig,and monitored the toxicity and allergic effects.Our results demonstrated that no cross-reaction was observed using influenza vaccine conjugating with H5N1 avian influenza vaccine,nor toxicity occurred,indicating the potential application of these two conjgated vaccines.