丙型肝炎病毒感染对维持性血液透析患者微炎症状态的影响

Influnence of hepatitis C virus infection on micro-inflammatory state in hemodialysis patients

【目的】探讨丙型肝炎病毒(HCV)感染对维持性血液透析(maintenance hemodialysis,MHD)患者微炎症的影响。【方法】比较30例HCV抗体阳性的维持性血液透析患者(阳性组)与30例HCV抗体阴性(阴性组)的维持性血液透析患者微炎症状态标志物:C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和白介素-6(interleukin-6I,L-6),同时检测并比较两组营养状况指标:血浆白蛋白(ALB)、前白蛋白(PA)。【结果】阳性组较阴性组血清CRPI、L-6和TNF-α水平均显著增高(P<0.05);阳性组ALB、PA组较阴性组显著降低(P<0.05)。【结论】感染HCV可加重维持性血液透析患者体内的微炎症状态,并进一步加重营养不良。

【Objective】 To investigate the influnence of hepatitis C virus infection on micro-inflammatory state in hemodialysis patients.【Methods】 Serum levels of markers of micro-inflammation including CRP、TNF-α and IL-6 were compared between anti-HCV antibody positive[HCV（＋）]and HCV（-）MHD patients.30 cases were enrolled in each group.Indications of nutritional status namely serum albumin and prealbumin were also compared.【Results】 Serum CRP,IL-6 and TNF-α levels of HCV（＋） group were significantly higher than those of the HCV（-） group（P 0.05） and serum albumin and prealbumin levels of the HCV（＋） group were significantly lower than those of the HCV（-） group（P 0.05）.【Conclusion】 HCV infection could aggravate micro-inflammatory state in MHD patients and further aggravate the malnutrition.