肥胖女性绝经前后及绝经年限与血脂水平变化的研究

To research relationship between pre-and post-menopausal periods and number of years after menopause with blood lipid level in obese women

目的探讨肥胖女性绝经前后及绝经年限与血脂变化的关系。方法女性肥胖组165例,测晨起空腹静脉血中甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),进行组间比较,并分析绝经年限与血脂水平的相关性。并与179例对照组比较。结果绝经前、后肥胖组LDL-C、TG显著高于对照组(P<0.05),HDL-C显著低于对照组(P<0.05);TG、TC、LDL-C在肥胖组及对照组绝经后显著高于绝经前(P<0.05),肥胖组HDL-C绝经后则显著低于绝经前组(P<0.05)。肥胖患者TC、LDL-C与绝经年限呈正相关(P<0.05);HDL-C与绝经年限呈负相关(P<0.05)。结论女性肥胖患者绝经后血TG、LDL-C增高,而HDL-C降低;TC、LDL-C与绝经年限呈正相关,HDL-C与绝经年限成负相关。

Objective To investigate the relationship between pre-and post-menopausal periods and number of years after menopause with lipid metabolism in obese women.Methods One hundred sixty-five obese women in pre-or post-menopausal periods were collected for the determination of blood triglycerides（TG）,total cholesterol（TC）,high density lipoprotein cholesterol（HDL-C）and low density lipoprotein cholesterol（LDL-C）.The blood lipid levels were compared between obesity and control groups,as well as between pre-and post-menopausal subgroups,and the relationship between number of years after menopause and blood levels lipid were analyzed.Results Obesity group in pre-and post-menopausal period had significantly higher TG and LDL-C than the control group respectively（P0.05）.lower HDL than the control group（P0.05）.In obesity post-menopause group and control post-menopausal group,TG、TC and LDL-C were significantly higher than pre-menopausal group（P0.05）.but HDL-C was lower than those in obesity pre-menopausal group.The levels of TC and LDL-C were positively correlated with number of years after menopause（P0.05）,HDL-C was negatively correlated with number of years after menopause.Conclusion In obesity post-menopause group,The levels of serum TG and LDL-C increase and HDL-C decrease after menopause.The levels of serum TC and LDL-C are positively correlated with number of years after menopause,HDL-C are negatively correlated with number of years after menopause.