子宫内膜异位症患者外周血干扰素γ、白细胞介素4和白细胞介素6的变化及其临床意义

Changes and clinical significance of peripheral blood interferon-γ,interleukin-4 and interleukin-6 in endometriosis

目的 探讨子宫内膜异位症（EM）患者外周血干扰素γ（IFN-γ）、白细胞介素4（IL-4）和白细胞介素6（IL-6）的变化及其临床意义.方法 用双抗体夹心酶联免疫吸附（ELISA）法检测25例EM患者（EM组）及20例盆腔结构正常患者（对照组）外周血IFN-y、IL-4、IL-6水平.结果 EM组患者外周血IFN-γ[（109.64±26.79）ng/L]明显低于对照组[（155.17±30.36）ng/L]（P＜0.05）,IL-4[（33.52±8.69）ng/L]、IL-6[（44.12±3.57）ng/L]明显高于对照组[（22.52±6.54）、（15.12±2.63）ng/L]（P＜0.05）;IFN-γ/IL-4（3.27±1.45）、IFN-γ/IL-6（1.15±0.56）明显低于对照组（6.89±1.68、2.54±1.03）（P＜0.01或＜0.05）.结论 EM患者有Th2细胞因子明显增多并占优势漂移的现象,Th1/Th2细胞因子失衡在EM的发病机制及疾病进展中可能具有重要的作用.

Objective To study the changes of interferon （ IFN ）- γ ,interleukin（IL）-4 and IL-6 in endometriosis. Method The levels of peripheral blood IFN-γ ,IL-4 and IL-6 in 25 patients with endometriosis （EM group） and 20 normal adults （control group） were detected by enzyme linked immunosorbent assay （ELISA）. Results The level of peripheral blood IFN- γ in EM group [（109.64±26.79 ） ng/L] was lower than that in control group [（155.17±30.36） ng/L] （P 〈 0.05 ）, IL-4[（33.52 ± 8.69）ng/L]and IL-6 [（44.12 ± 3.57） ng/L] were higher than those in control group [（22.52 ± 6.54）, （ 15.12 ±2.63 ）ng/L]（P〈0.05 ）.The ratio of IFN-γ/II-4（3.27±1.45 ） and IFN- γ/IL-6 （ 1.15 ± 0.56 ） in EM group were significantly lower than those in control group （6.89 ±1.68,2.54 ±1.03）（P 〈0.01 or 〈0.05）.Conclusions Th1 cells shift toward Th2 cells in patients with endometriosis. Th1/Th2 ratio may be correlated with the pathogenesis of endometriosis.