摘要
目的:了解慢性吸烟者是否存在脑灰质改变。方法:采用磁共振三维成像技术对44名吸烟者和44名相匹配的不吸烟者脑结构扫描,利用基于体素的形态学分析方法进行吸烟与非吸烟者两组之间的脑灰质体积比较。结果:与不吸烟者组相比,吸烟者组的左侧丘脑、额中回区和扣带回灰质体积下降(P<0.001,未纠正)。结论:本研究发现了慢性吸烟者的脑灰质改变(丘脑、额中回区和扣带回灰质体积下降),此结果将有助于进一步研究慢性吸烟的大脑作用机制。
Objective： Assessing volumetric abnormalities of grey matter in chronic cigarette smokers.Methods：We used three-dimensional structural magnetic resonance images and voxel-based morphometry method in 44 smokers and 44 non-smoking control individuals to assess gray matter volume differences between the two groups.Results：We found a decrease in gray matter volume in left thalamus,medial frontal cortex and anterior cingulate of smokers in comparison to controls（P0.001 uncorrected for multiple comparisons at voxel-level）.Conclusion：This study showed the reduction of regional（left thalamus,medial frontal cortex and anterior cingulated） gray matter volume in smokers.Those results might better guide future research into the pathogenesis of chronic smoking.
出处
《中国药物依赖性杂志》
CAS
CSCD
2011年第2期101-104,共4页
Chinese Journal of Drug Dependence
基金
973课题2007CB512301
2007BAI07B0
国家自然科学基金30870893
30971050
30900486资助
