小剂量垂体后叶素加单硝酸异山梨酯治疗肝硬化并发食管胃底静脉曲张破裂出血疗效观察

Curative effect of low dose of vasopressin and isosorbide mononitrate in treating esophageal and gastrical bottom varicosis rupture hemorrhage in hepatic cirrhosis

目的探讨小剂量垂体后叶素加单硝酸异山梨酯治疗肝硬化并发食管胃底静脉曲张破裂出血的疗效。方法将88例肝硬化并发食管胃底静脉曲张破裂出血患者随机分成三组，33例给予小剂量垂体后叶素（0．1U／min）和单硝酸异山梨酯联合治疗，27例单用垂体后叶素（0．2U／min）治疗，28例用善得定治疗。结果小剂量垂体后叶素加单硝酸异山梨酯组、单用垂体后叶素组、善得定组止血有效率分别为81．8％、59．3％、85．7％。经×。检验，小剂量垂体后叶素加单硝酸异山梨酯组与单用垂体后叶素组比较差异有统计学意义（P〈0．01），而与善得定组比较差异无统计学意义（P〉0．05）。结论小剂量垂体后叶素和单硝酸异山梨酯联用止血疗效显著。

Objective To investigate the curative effect of low dose of vasopressin and isosorbide mononitrate in treating esophageal and gastrical bottom varicosis rupture hemorrhage in hepatic cirrhosis. Methods Eighty - eight patients with esophageal and gastrieal bottom varieosis rupture hemorrhage in hepatic cirrhosis were divided into three groups randomly. Thirty - three cases were treated with low dose of vasopressin （0. 1 U/rain） and isosorbide mononitrate, 27 cases were treated with single vasopressin （0.2 U/rain） , and 28 cases with sandostatin. Results The control rates of bleeding were 81.8% ,59.3% and 85.7% , respectively. By X2 test, the combined therapy group （vasopressin and isosorbide mononitrate） was significantly different from vasopressin group （P 〈 0.01 ）, but not from sandostatin group （ P 〉 0.05 ）. Conclusions The results indicated that combination of low dose of vasopressin and isosorbide mononitrate could significantly reduce hemorrhage and obtained an eminent curative effection.