可回收手性配体催化烯烃不对称氨羟化反应研究

Study on the Asymmetric Aminohydroxylation of Olefins Catalyzed by a Free Recoverable and Reusable Ligand

一种可重复使用的非支载型金鸡纳生物碱衍生物配体与金属锇形成原位催化剂用于催化5种肉桂酸甲酯类烯烃的不对称氨羟化（AA）反应,表现了好的对映选择性（91%~96%）和反应活性（52%~72%）.在以对甲基肉桂酸甲酯为底物的AA反应中,采用了两种不同的回收方法,均能有效地进行配体的回收和再利用,配体的催化活性和对映选择性基本保持不变.该手性配体用于催化AA反应,可以制备光学活性的α-氨基酸酯类化合物.

A reusable free cinchona alkaloid derivative ligand was applied to asymmetric aminohydroxylation（AA） of 5 five methyl cinnamates with 91%-96% e.e.and 52%-72% yields.In the AA reaction of methyl cinnamates,this ligand can be easily recovered and reused without any significant loss in its catalytic efficiency by two defferent methods.this ligand was applied to the catalytic asymmetric aminohydroxylation to produce enantioselective α-aminoacid esters.