摘要
[目的]探讨奥氮平对精神分裂症患者认知功能的影响.[方法]对本院52例精神分裂症患者使用奥氮平治疗8周,于治疗前及治疗后使用阳性和阴性症状量表(Positive and Negative Syndrome Scale, PANSS)、韦氏记忆量表(Wechsler Memory Scale,WMS)和威斯康星卡片分类测验(Wisconsin Card Sorting Test, WCST)进行评估.[结果]治疗8周后,PANSS总分显著降低[(43.12±13.83) vs (77.68±12.14),P〈0.01];WCST中错误应答数、非持续性错误的分值显著降低(P〈0.05);WMS中记忆商(memory quotient,MQ)、再生和理解的分值显著升高(P〈0.05).[结论]奥氮平治疗精神分裂症可改善患者的认知功能.
[Objective]To explore the effect of olanzapine on the cognitive function of schizophrenia patients. [Methods] Fifty two patients with schizophrenia in out hospital were given olanzapine for 8 weeks. The positive and negative syndrome scale(PANSS), Wechsler memory scale(WMS) and Wisconsin card sorting test(WCST) were used to evaluate before and after treatment. [Results]After 8 weeks of treatment, the score of PANSS was decreased signifieantly[(43.12±13. 83) vs (77.68±12.14), P 〈0. 01]. The scores of fault answer and un-durative fault in WCST decreased significantly( P 〈0.05). The memory quotient(MQ) and scores of reactive and comprehension in WMS increased significantly ( P 〈0.05). [Conclusion]Olanzapine can improve the cognitive func tion of schizophrenia patients.
出处
《医学临床研究》
CAS
2011年第3期445-446,共2页
Journal of Clinical Research