两种化疗方案治疗妊娠滋养细胞肿瘤的疗效观察

Observation on the Efficacy of Two Kinds of Chemotherapy Schemes for the Treatment of Gestational Trophoblastic

[目的]探讨两种化疗方案治疗妊娠滋养细胞肿瘤（GTN）的疗效.[方法]对本院于2003年5月至2008年5月收治50例GTN患者采取非同期非随机对照,分配到5-FU＋更生霉素（KSM）化疗组和EMA/CO 化疗组,对方案两组的有效率和毒副反应进行比较分析.[结果]5-FU＋KSM化疗方案和EMA/CO化疗方案的有效率分别为85%和93%,差异无显著性,比较骨髓抑制差异无显著性,但胃肠道反应（恶心、呕吐、腹泻）肝、肾功能损害,口腔溃疡比较,差异均有显著性.[结论]EMA/CO化疗方案,是治疗恶性滋养细胞肿瘤一种既有效,又产生毒副作用轻、患者容易接受的化疗方案.

[Objective] To explore the efficacy of two kinds of chemotherapy schemes for treatment of gestational trophoblastic tumor（GTT）. [Methods] Fifty GTT patients in our department from May 2003 to May 2008 were assigned to 5-FU＋ KSM chemotherapy group and EMA/CO chemotherapy group by using asynchronous non-randomized controlled method. The effective rate and adverse reaction were analyzed and compared between two groups. [Results] The effective rate of 5-FU＋KSM chemotherapy scheme and EMA/CO chemotherapy scheme were 85% and 93%, respectively, and the difference had no statistical significance. There was no significant difference in bone marrow depression between two schemes. But there were significant differences in gastrointestinal reactions（nausea, vomiting and diarrhea）, liver and kidney impairment and oral ulcer between two schemes. [Conclusion]EMA/CO scheme for the treatment of GTT is an effective and acceptable chemotherapy scheme with slight side effects.