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氯沙坦与依那普利对高血压患者颈动脉内膜中层厚度的影响 被引量：1

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摘要 [目的]探讨氯沙坦与依那普利在降低颈动脉内膜中层厚度中的作用.[方法]本院门诊治疗的原发性高血压患者126例,随机分为两组,A组患者服用氯沙坦治疗;B组患者服用依那普利治疗,对两组患者治疗前后的高血压及颈动脉内膜中层厚度（IMT）进行测定并进行统计学分析.[结果]两组患者药物治疗后,血压均获得较好的控制,治疗后4、8、16周血压均逐步下降,其中4、8、16周血压下降与治疗前血压对比有统计学意义（P〈0.05）.两组患者用药后IMT逐渐降低,其中治疗后8、16周两组治疗组IMT均较治疗前为低,并对比结果有统计学差别（P〈0.05）.而在治疗后16周中A组IMT为（0.663±0.178mm）,显著低于B组的（0.716±0.189）mm,两组对比有统计学差异（P〈0.05）.[结论]氯沙坦及依那普利在降低患者高血压方面均疗效显著,且在本次实验中,氯沙坦降低颈动脉内膜中层厚度作用优于依那普利.
作者 张明辉 杨玉斌 赵杰
机构地区 北京市西城区平安医院内科
出处 《医学临床研究》 CAS 2011年第3期544-545,共2页 Journal of Clinical Research
关键词 高血压/药物疗法 洛沙坦/药理学 依那普利/药理学 颈动脉 内皮 血管
分类号 R544.1 [医药卫生—心血管疾病]
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参考文献6

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二级参考文献9

共引文献1

同被引文献13

  • 1沙坦类药物的降压外作用[J].中华高血压杂志,2007,15(3):177-179. 被引量：13
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医学临床研究
2011年 第3期

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