自拟补肾强脊通络汤加中药熏蒸治疗强直性脊柱炎172例临床研究

The clinical research of treating 172 cases of spondylitis ankylosing patients with Bushen Qiangji Tongluo decoction plus TCM fumigation

目的:观察自拟补中药方内服加熏蒸治疗强直性脊柱炎的作用机制和临床优势。方法:将172例患者随机分组实验组给予自拟中药方水煎内服加局部熏蒸治疗,配合静滴川芎嗪注射液;对照组给予口服柳氮磺吡啶、雷公藤多甙、强的松等药物治疗,同样静滴川芎嗪注射液。结果:实验组临床显效率83.03%、好转率15.18%、总有效率98.21%、不良反应发生率8.04%对照组分别为70.00%、15.00%、85.00%、35.00%。两组显效率和总有效率比较差异均有统计学意义(P均<0.05),实验组明显优于对照组;两组不良反应发生率比较差异也有统计学意义(P均<0.05),实验组明显低于对照组。结论:实验组的治疗方法和治疗效果均达到国内先进水平,并且具有效果显著、简便实用、毒副作用小、痛苦小、费用低、长期疗效可靠、病人易于接受等优点,具有较高的社会效益和经济效益,适合于各级医院推广。

Objective： To observe the function mechanism and clinical advantages of treating spondylitis ankylosing with TCM plus fumigation. Methods： Randomly divided 172 patients into two groups, in which, the experimental group with the treating of drinking TCM decoction plus partly fumigation treatment and Chuan Qiong hydrochloride while the control group with the treatment of oral sulfasalazine, TWP, prednisone and so on. At the same time, they also with Chuan Qiong hydrochloride. Results： The clinical effective rate of the experiment group was 83.03%, the improvement rate was 15.18%, the total effective rate was 98.21%, the incidence of adverse reactions rate was 8.04%; While the control group were 70.00%, 15.00%, 85.00%, 35.00%. Comparing the difference between the two groups, there was obvious statistical meaning （P〈0.05）, which shows that the experimental group is obviously surpass than the control group, so as the incidence of adverse reaction rate. Conclusion： The experi -ment group＇s methods and results have corned to the domestic advanced level, and made a significant effect, it＇s simple and practical, drug side ef -fects, less painful, low cost, long-term efficacy, reliable and easy to be accepted by the patients. It is also with high social and economic effective, suitable for all levels of the hospitals.