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双重酪氨酸激酶抑制剂Lapatinib治疗转移性乳腺癌的研究进展 被引量:1

Research Progress in Dual Tyrosine Kinase Inhibitor Lapatinib in the Treatment for Metastatic Breast Cancer
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摘要 Lapatinib是一类口服的双靶点小分子酪氨酸激酶抑制剂(TKI),同时作用于表皮生长因子受体(EGFR)和Her-2两个靶点。体内外的临床前实验证明Lapatinib抗肿瘤活性,临床试验结果表明其对ErbB2过度表达的晚期乳腺癌有较好的疗效,并可能减少脑转移的发生率,而且耐受性良好。
作者 刘欣 王宝成
机构地区 济南军区总医院
出处 《肿瘤学杂志》 CAS 2011年第3期165-167,共3页 Journal of Chinese Oncology
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