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MDR1基因单核苷酸多态性与肝细胞肝癌预后的关系 被引量：3

Correlation of MDR1 Single Nucleotide Polymorphism with Prognosis of Hepatocellular Carcinoma
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摘要 [目的]探讨多药耐药基因1(multidrug resistance gene 1,MDR1)C1236T及C3435T单核苷酸多态性(SNP)与肝细胞肝癌(HCC)预后间关系。[方法]以36例HCC根治术患者为对象,同时建立50例对照组,PCR-SSCP法检测其静脉血标本C1236T及C3435T SNP,比较分析C1236T及C3435T SNP与HCC预后的关系。[结果]HCC组与对照组的基因分布无统计学差异(P>0.05)。C3435T基因型CC、CT、TT型中位无瘤生存时间依次为164.5d、340.0d和369.5d,C1236T基因型CC、CT、TT型中位无瘤生存时间依次为201.0d、415.0d、260.0d,MDR1基因多态性与HCC复发相关。[结论]C3435T SNP可作为肝癌根治术的预后因素之一。
作者 陈徐艰 王晓光 沈亦珏 周鸿鲲 倪全法 费建国 钟征翔
机构地区 嘉兴医学院附属第二医院
出处 《肿瘤学杂志》 CAS 2011年第3期209-211,共3页 Journal of Chinese Oncology
基金 嘉兴市科技局基金项目(2008AY2034-5)
关键词 肝肿瘤 预后 单核苷酸多态性 多药耐药
分类号 R735.7 [医药卫生—肿瘤]
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参考文献1

二级参考文献24

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共引文献5

同被引文献26

  • 1赵澎,胡微,张亚卓,孙梅珍,何乐.RNA干扰技术逆转神经胶质瘤细胞多药耐药性[J].中华肿瘤杂志,2006,28(3):183-187. 被引量：19
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引证文献3

二级引证文献14

肿瘤学杂志
2011年 第3期

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