角蛋白19片段K19-2G2检测在肺癌中的临床意义

Cytokeratin 19 Fragment K19-2G2 Detection in Lung Cancer

[目的]探讨角蛋白19片段K19-2G2检测在肺癌中的临床意义。[方法]应用化学发光免疫分析法和电化学发光法检测345例肺癌、150例肺部良性疾病和500例健康体检者(对照组)血清K19-2G2和CYFRA21-1。[结果]肺癌组患者血清K19-2G2和CYFRA21-1浓度均显著高于肺部良性疾病和对照组(P<0.01);K19-2G2检测对肺癌的灵敏性和特异性分别为61.45%和97.69%均高于CYFRA21-1(P<0.05)。K19-2G2和CYFRA21-1在非小细胞肺癌的血清浓度显著高于小细胞肺癌(P均<0.05)。早期非小细胞肺癌和进展期非小细胞肺癌血清K19-2G2浓度和阳性率相近。[结论]K19-2G2对肺癌尤其是非小细胞肺癌的具有较高的灵敏性和特异性,可能有助于非小细胞肺癌早期诊断。

[Purpose] To investigate the clinical significance of cytokeratin 19 fragment K19-2G2 detection in lung cancer.[Methods] K19-2G2 and CYFRA21-1 in 345 cases with lung cancer,150 cases with lung benign disease and 500 health volunteers（control group） were detected by chemiluminoimmunoassay and electrochemiluminescence methods.[Results] The serum content of K19-2G2 and CYFRA21-1 was significantly elevated in patients with lung cancer compared those with lung benign diseases（P0.01） or normal control group（P0.01）.The sensitivity and specificity of K19-2G2 detection in lung cancer were 61.45% and 97.69% respectively,with significantly higher than those of CYFRA21-1（P0.05）.The serum content of K19-2G2 and CYFRA21-1 in non-small cell lung cancer was significantly higher than those in small cell lung cancer（P0.05）.The serum content and positive rate of K19-2G2 in patients with early stage non-small cell lung cancer were similar to those in advanced non-small cell lung cancer.[Conclusion] K19-2G2 is sensitive and specific to lung cancer diagnosis,especially in non-small cell lung cancer.It is helpful to diagnose for non-small cell lung cancer in early stage.