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短期胰岛素泵强化治疗初诊2型糖尿病的临床观察 被引量:3

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摘要 目的:观察短期胰岛素泵强化治疗对初诊的2型糖尿病(T2DM)患者血糖的控制、β细胞功能改善情况,探讨影响治疗成功的相关因素。方法:对54例初诊的T2DM患者进行为期2周的胰岛素泵强化治疗。分析比较治疗前、后空腹及餐后2h血糖、C肽的变化;根据停用胰岛素泵1周后(仅采用饮食运动控制)血糖变化情况分为治疗成功组和失败组,并对相关因素进行比较分析。结果:2周的胰岛素泵治疗可使所有患者的血糖有效、稳定下降,治疗后C肽明显提高,差异有统计学意义(P<0.01);21例患者在停用胰岛素泵治疗后采用饮食控制及运动锻炼血糖保持正常。成功组与失败组相比年龄较轻,强化治疗结束时胰岛素用量小,C肽提高明显,差异有统计学意义(P<0.05)。结论:对初诊2型糖尿病患者,短期胰岛素泵强化治疗可快速、稳定的控制血糖,改善β细胞功能;年轻、强化治疗结束时胰岛素用量少、β细胞功能恢复良好的患者将来仅通过饮食运动疗法获得良好的血糖控制的可能性大。
作者 杜琳 艾隽
出处 《新疆医学》 2011年第3期55-57,共3页 Xinjiang Medical Journal
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参考文献6

  • 1Purrell O F, Rabuazza AM. MetaboliC factors that beta-Cell function and survival. J Diabetes NutrMetab ,2000,13 : 84-91.
  • 2SivitzWI .Lipotoxieuty and glueotoxieity in type 2 diabetes. Effects on development and progression. J Postgrad Med 2001,109:55-59,63 - 64.
  • 3Ilkova H, Glaser B, Tunckale A, et al. Induction of long- time glycemic control in newly diagnosed type 2 diabetic patients by transient intensive insulin treatment [ J], Diabetes Care, 1997,20 ( 7 ) : 1353- 1356.
  • 4祝方,纪立农,韩学尧,朱宇,张红杰,周翔海,陈静,蔡晓陵,张明霞.短期胰岛素强化治疗诱导初诊2型糖尿病患者血糖长期良好控制的临床试验[J].中国糖尿病杂志,2003,11(1):5-9. 被引量:856
  • 5Ryan EA, Imes S, Wallace C. Short term intent sive insulin therapy in newly diagnosed type 2 diabetes. Diabetes care ,2004,27 : 1028-1032.
  • 6张波,安雅莉,巩秋红,帅英,卜石,陈燕燕,张金苹,杨文英,刘雪丽,李光伟.短期胰岛素强化治疗诱导2型糖尿病患者长期缓解的预测因素[J].中华内分泌代谢杂志,2007,23(2):134-138. 被引量:95

二级参考文献16

  • 1李光伟,宁光,周智广.2型糖尿病早期胰岛素强化治疗改善胰岛β细胞功能——是现实还是梦想?[J].中华内分泌代谢杂志,2006,22(4):309-312. 被引量:223
  • 2Weyer. Dificiency in AIR predict IGT and Type 2 diabetes. Diabetes Care, 2001,24 : 89-94.
  • 3Haffner SM, Miettinen H, Gaskill SP, et al. Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans. Diabetes, 1995,44: 1386-1391.
  • 4Bruce DG, Chisholm DJ, Leonare H, et al. Physiological importance of deficiency in early prandial insulin secretion in non-in-sulin-dependent diabetes. Diabetes, 1988,37: 736-743.
  • 5Bruttomesso D, Pianta A, Mari A, et al. Restoration of early rise in plasma insulin levels improves the glucose tolerance of type 2 diabetic patients. Diabetes, 1999,48: 99-105.
  • 6Ilkova H, glaser B, Tunckale A, et al. Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients by transient intensive insulin treatment. Diabetes Care, 1997,20:1353-1356.
  • 7Walton C, Godsland IF, Proudler AJ, et al. Effect of body mass index and fat distribution on insulin sensitivity, secretion, and clearance in nonobese healthy men. J Clin Endocrinol Metab,1992,75: 170-175.
  • 8llkova H,Glaser B, Tunckale A, et al. Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients by transient intensive insulin treatment. Diabetes Care, 1997,20 : 1353-1356.
  • 9Floch JPL, Escuyer P, Baudin E, et al. Blood glucose area under the curve : methodological aspects. Diabetes Care, 1990,13 : 172-175.
  • 10Li Y, Xu W, Liao Z, et al. Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of β-cell function. Diabetes Care, 2004,27:2597-2602.

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