颈动脉粥样硬化程度与急性脑梗死相关性探讨研究

Study on the Relationship of Carotid Atherosclerosis and Acute Cerebral Infarction

目的 探讨颈动脉粥样硬化的危险因素及硬化程度与急性脑梗死的相关性.方法 选择急性脑梗死病例60例,正常健康体检对照40名,对其血糖、血脂、纤维蛋白原、血压、颈动脉粥样硬化程度等进行对照分析,同时将颈动脉粥样硬化的程度与脑梗死病人临床表现进行对照分析,探讨它们之间的相关性.结果 急性脑梗死组与正常对照组相比,血糖、胆固醇（TC）、低密度脂蛋白（LDH-C）、纤维蛋白原（FIB）含量以及高血压、吸烟、饮酒者比率均明显增高（P〈0.05）,颈动脉粥样硬化内膜厚度、斑块形成及狭窄发生率,两组相比有明显差异（P〈0.05）,颈动脉粥样硬化斑块形成、管腔狭窄〈50%与≥50%脑梗死病人的临床症状不同,神经功能缺损评分（NIHSS评分）相比差异显著（P〈0.05）.结论 血糖、血脂、纤维蛋白原含量增高以及颈动脉粥样硬化、高血压、吸烟、饮酒是急性脑梗死的易患因素,颈动脉粥样硬化斑块形成及管腔狭窄的程度与患者的病情轻重密切相关.

Objective To investigate carotid atherosclerosis risk factors and sclerosis hardenability in patients with acute cerebral infarction. Methods 60 cases of acute cerebral infarction patients,the normal physical exam compares 40 cases,two groups of patients on blood glucose,blood lipids,fibrinogen, blood pressure,carotid atherosclerosis were compared,while carotid atherosclerosis the degree of clinical manifestations of patients with cerebral infarction were compared to explore the correlation between them.Results The acute cerebral infarction group and the normal control group,blood glucose,cholesterol,low density lipoprotein,fibrinogen levels and high blood pressure,smoking, drinking rates were significantly higher（P〈0.05）,carotid artery intimal thickness of atherosclerotic plaque formation and stenosis rate,there were significant differences between the two groups（P〈0.05）,carotid atherosclerotic plaque,stenosis 〈50% and〉..-50% of the clinical symptoms of cerebral infarction patients with different neurological deficit score（NIHSS score） compared with significant difference（P〈0.05）.Conclusion The blood glucose,blood lipids,fibrinogen level increased and carotid atherosclero- sis,hypertension, smoking,alcohol risk factors of acute cerebral infarction, carotid artery atherosclerotic plaque and the degree of stenosis are closely related to the severity of patients.