HRG-1基因在膀胱癌和正常膀胱组织中的表达

Expression of HRG-1 gene in carcinoma of urinary bladder and normal bladder tissues

目的观察HRG-1基因在膀胱正常组织和膀胱癌组织中的表达,探讨HRG-1基因表达与膀胱肿瘤病理分级和临床分期的关系。方法应用免疫组化SP法检测63例膀胱癌和28例膀胱正常组织石蜡标本中HRG-1表达情况,并进行相关临床病理分析。结果在正常膀胱组织和膀胱癌组织中HRG-1表达有显著性差异(P<0.05);HRG-1的阳性表达与膀胱癌病例分级、临床分期之间有显著性差异(P<0.05)。结论 HRG-1基因在膀胱癌组织中表达水平显著提高,提示该基因可能对膀胱肿瘤病理分级和临床分期有一定的指导意义。

Objective To observe HRG-1 gene expression in carcinoma of urinary bladder and normal urinary bladder tissues,and to explore the relationship between HRG-1 gene expression and bladder tumor pathologic stage and the clinical stages.Methods Immunohistochemisty was used to detect the expression of HRG-1 in 63 cases of bladder cancer and 28 normal bladder tissues.Results HRG-1 gene expression had significant differences between bladder cancer and normal bladder tissues（P0.05）;HRG-1 gene positive expression had marked differences between the pathological grades and clinical stages of bladder cancer（P0.05）.Conclusions The high expression of HRG-1 gene may play an important role in bladder cancer,and may served as valuable indicators of the pathological grades and clinical stages of bladder cancer.