过氧化物酶体增殖物激活受体γ激动剂抗转化生长因子-β促器官纤维化作用的研究进展

Research Advancements of Peroxisome Proliferator-Activated Receptor γ Agonists Inhibiting Transforming Growth Factor-β-Induced Organ Fibrosis

目的总结过氧化物酶体增殖物激活受体γ(PPARγ)激动剂抗转化生长因子-β(TGF-β)促器官纤维化作用的研究进展。方法复习有关PPARγ激动剂抗TGF-β促器官纤维化作用的文献并进行综述。结果 TGF-β是一种主要的促纤维化细胞因子,能促进多种器官的纤维化进程,而PPARγ激动剂则可以有效地阻断TGF-β的信号传导,从而发挥抗器官纤维化的作用。结论研究PPARγ激动剂主要通过阻断TGF-β信号传导来实现抗器官纤维化的机理,有助于PPARγ激动剂在临床上的推广运用,为治疗器官纤维化疾病提供一种新途径。

Objective To summarize the research advancement of peroxisome proliferator-activated receptor γ（PPARγ） agonists inhibiting transforming growth factor-β（TGF-β）-induced organ fibrosis.Methods The related literatures on PPARγ agonists inhibiting TGF-β-induced organ fibrosis were reviewed.Results TGF-β was a major fibrosis-promoting cytokine,which could promote a variety of organ fibrosis.PPARγ agonists could effectively block TGF-β signal transduction,and then suppressed organ fibrosis well.Conclusions The main antifibrotic mechanism of PPARγ agonists is to inhibit TGF-β signal transduction.The studies on this mechanism will help promoting the clinical application of PPARγ agonists,and provide a new way of the treatment for organ fibrosis.