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RNA干扰技术在生物医学领域中的应用 被引量：1

Application of RNA interference technology in biomedicine
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摘要 RNA干扰(RNAi)是由双链RNA(dsRNA)启动的序列特异的转录后基因沉默过程。在这一过程中,dsRNA被核酸内切酶切割成小干扰RNA(siRNA),siRNA与相关的蛋白结合成RNA诱导沉默复合体,这一复合体可识别并降解mRNA,导致基因沉默。它是一种比反义寡聚核苷酸技术更为有效的方法,具有更高的特异性,在生物医学领域有广阔的应用前景。文章就RNAi技术在功能基因组学、基因治疗(如人类免疫缺陷病毒、肝炎病毒、肿瘤)、神经性疾病及其药物设计等领域的实验及其应用研究及存在问题作一综述。
作者 曾雪爱 洪炎国 黄俊山
机构地区 福建师范大学生命科学学院福建省发育和神经生物学重点实验室 福建省中医药研究院福建省老年脑功能障碍重点研究室
出处 《生物医学工程与临床》 CAS 2011年第2期189-192,共4页 Biomedical Engineering and Clinical Medicine
基金 福建省中医药科研项目重点课题(wzzs0902) 福建省中西医结合老年性疾病重点实验室开放课题 陈可冀中西医结合发展基金(2008J1004-25 CKJ2008062)
关键词 RNA干扰 功能基因组学 基因治疗 神经性疾病
分类号 R318.0 [医药卫生—生物医学工程]
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同被引文献28

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生物医学工程与临床
2011年 第2期

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