HPV感染年龄与高度宫颈上皮内瘤变的关系

Research on the relationship of HPV infection and cervical precancerous lesions

目的探讨高危型人乳头瘤病毒(HR-HPV)感染患者年龄分布与高度宫颈上皮内瘤变和宫颈癌的关系。方法 2008年7月至2009年4月在中日友好医院同时采用液基薄层细胞学(LCT)和HPV检测行宫颈癌筛查的妇女948例,对LCT≥ASC-US和/或HR-HPV阳性的367例患者进行阴道镜下宫颈活检。结果 <50岁年龄组妇女的HR-HPV感染率(34.27%)与≥50岁年龄组妇女(18.98%)比较,差异具有统计学意义(P<0.01);<30岁、30～49岁和≥50岁3个年龄组HR-HPV阳性者中,≥CIN2患者的例数分别为18例(39.13%)、81例(43.78%)和17例(32.69%),差异无统计学意义(P>0.05)。结论各个年龄段感染HR-HPV的妇女发生≥CIN2的机会无明显差异,均应加强随访。

Objective To investigate the relationship of HR-HPV infection and cervical precancerous lesions.MethodsLiquid-based cytologic test（LCT）and HPV were performed in 948 women in China-Japan friendship hospital from July 2008 to April 2009.For the 367 patients with the abnormal cytological results or positive HR-HPV DNA,biopsy were done under colposcope.ResultsThere was significant difference in HR-HPV infection rates between women younger than 50 years（34.27%）and older than 50 years（18.98%）（P0.01）.Among positive HR-HPV women,there was no significant difference in the ratios of pkemalignancy ≥CIN2 in different age groups（30、30～49 and ≥50 years old）（P0.05）.ConclusionsIt＇s important to under follow-up for women with positive HPV DNA of each age group.