2型糖尿病患者糖链抗原19-9与尿清蛋白变化关系的探讨

Study on the Relationship between Serum Carbohydrate Antigen 19-9 Levels and Urine Albumin in Type 2 Diabetes Mellitus Patients.

目的探讨2型糖尿病患者糖链抗原19-9与尿清蛋白变化的关系。方法 2009年8月～2010年6月在本科住院205例2型糖尿病患者入组,测定血糖链抗原19-9、空腹血糖、糖化血红蛋白、血脂、尿清蛋白及肾小球滤过率值等,通过B超及CT检查排除胰腺肿瘤,最后通过统计方法分析糖链抗原19-9与尿清蛋白及肾小球滤过率的关系。结果 205例患者影像学检查均正常,尿清蛋白与糖链抗原19-9水平呈显著正相关(r为0.388,P为0.000),与肾小球滤过率呈负相关(r为-0.225,P为0.001)。通过尿清蛋白分层,经单因素方差分析显示大量清蛋白尿组显著高于微量蛋白尿组及正常清蛋白尿组(P分别为0.003,0.000)。而通过糖尿病病程分层,各组间糖链抗原19-9并无显著统计学差异(F为0.322,P为0.809)。结论 2型糖尿病患者糖链抗原19-9与尿清蛋白相关,尿清蛋白是糖链抗原19-9的重要影响因素。

Objective To study on the relationship between serum carbohydrate antigen 19 -9 （CA19 -9）levels and urine albumin in type 2 diabetes mellitus patients. Methods The study was conducted in 205 hospitalized patients with type 2 diabetes mellitus from August 2009 to June 2010. CA19 -9, fasting plasma glucose, hemoglobin A1 c, lipid profile, urine albumin and glomeruar filtration rate were measured. Abdominal B and uhrasonicor CT were performed in order to eliminate abdominal malignancy. The relationship between serum CA19 -9 levels, urine albumin and glomeruar filtration rate were analyzed. Results Abdominal B and ultrasonicor CT showed no pancreatic malignancy for all patients. There was a significantly positive correlation between urine albumin and CA19 - 9 level （r = 0. 388, P = 0. 000） , and a negative correlation with glomeruar filtration rate （ r = - 0. 225, P = 0. 001 ）. Serum CA19 - 9 level of macroalbuminuria group was significantly higher than that of microalbuminuria or normoalbuminuria group （P = 0. 003, 0. 000）. But the changes of CA19 - 9 levels were not statistically correlated to duration of diabetes in four groups（ F = 0. 322,P = 0. 809）. Conclusion Serum CA19 -9 was related to urine albumin in patients with type 2 diabetes mellitus, which was an important risk factor for CA19 -9.