内皮祖细胞与氧化应激研究进展

Research progress of endothelial progenitor cells and oxidative stress

背景:内皮祖细胞是外周血中存在的一种干/祖细胞,是成熟内皮细胞的前体细胞,其与氧化应激的关系越来越受到人们的关注,而且国内外研究正日趋增多。目的:对国内外内皮祖细胞与氧化应激关系的现状及新进展作一综述。方法:应用计算机检索CNKI和Pubmed数据库中1997-01/2010-05关于内皮祖细胞与氧化应激的文章,在标题和摘要中以"内皮祖细胞,氧化应激"或"endothelial progenitor cells,oxidative stress"为检索词进行检索。选择文章内容与内皮祖细胞与氧化应激有关者,同一领域文献则选择近期发表或发表在权威杂志文章。初检得到212篇文献,最终选择有代表性的34篇文献进行综述。结果与结论:内皮祖细胞与氧化应激关系密切,虽然内皮祖细胞具有比成熟内皮细胞更强的抗氧化能力,但在长期氧化应激存在的情况下,氧化应激通过减弱其抗氧化酶的表达,增加氧化酶的表达而促进内皮祖细胞的凋亡而影响其功能及数量,故氧化应激是导致内皮祖细胞数量改变及功能受损的影响因素之一,而通过他汀类药物、血管紧张素转换酶抑制剂/受体拮抗剂及过氧化物酶体激动剂的干预可改善内皮祖细胞的氧化应激状态,保护其功能。

BACKGROUND：Endothelial progenitor cells（EPCs）,known as the precursor cells of mature endothelial cells,is a type of stem/progenitor cells in peripheral blood.Recently,the relationship of EPCs to oxidative stress has become a hotspot in research area.OBJECTIVE：To review the new publications on the relationship between EPCs and oxidative stress.METHODS：The articles on EPCs and oxidative stress were searched through CNKI and Pubmed database published from January 1997 to May 2010.The key words were ＂endothelial progenitor cells,oxidative stress＂ that were searched in titles and abstracts.The articles concerning endothelial progenitor cells and oxidative stress were selected.In the same field,articles published recently or in authoritative journals were selected.A total of 212 articles were selected through the first search,and finally 34 papers were reviewed by the inclusion criterion.RESULTS AND CONCLUSION：EPCs were closely associated with oxidative stress.The anti-oxidative stress capability of EPCs was better than that in mature endothelial cells.However,with the chronic oxidative stress,the apoptosis is promoted by the decreased expression of antioxidase and increased expression of oxidase,which impairs the function and decreases the quantities of EPCs.Therefore,oxidative stress is one of factors leading to the changes in the quantity and function of EPCs.The intervention of statins,angiotensin converting enzyme inhibitor/receptor antagonist and peroxisome activator may release the oxidative stress in EPCs and protect the function of EPCs.