脐血间充质干细胞移植治疗低血糖昏迷1例

Umbilical cord blood mesenchymal stem cells transplantation for treating hypoglycemic coma in one case

背景:成体干细胞可以跨系跨胚层分化为所有的组织细胞类型,在特定的条件下,可分化为骨、软骨、脂肪、肌肉和神经细胞等,替代、修复已受损的组织、细胞,达到功能修复的目的。目的:观察脐血间充质干细胞治疗低血糖昏迷并发缺氧缺血性脑病的疗效。方法:对收治的1例低血糖昏迷并发缺氧缺血性脑病及肺部感染的患者,给予抗自由基、营养神经、促醒、抗感染、康复理疗等综合治疗的同时,从静脉滴注进行脐血间充质干细胞治疗。观察住院期间意识恢复情况、脑电图、日常生活能力评分及随访结果。结果与结论:治疗近1个月后患者运动、认知功能明显恢复,复查脑电图可及a波,日常生活活动能力评分50分,70d后随访,患者未出现不良反应,表明干细胞治疗近期疗效安全。提示脐血间充质干细胞治疗低血糖昏迷并发缺氧缺血性脑病安全有效。

BACKGROUND：Adult stem cells can differentiate into all kinds of cell type.Under special conditions,adult stem cells can differentiate into osteoblasts,chondrocytes,adipocytes,muscle cells and neural cells to replace and to repair damaged tissues and cells,to achieve functional recovery purposes.OBJECTIVE：To observe the effect of umbilical cord blood mesenchymal stem cells（UCB-MSCs） therapy in hypoglycemic coma combined with hypoxic ischemic encephalopathy.METHODS：One case of hypoglycemic coma combined with hypoxic ischemic encephalopathy and pulmonary infection was admitted.This patient received a combined treatment,including anti-free radical,nerve-nurturing,consciousness-regaining,anti-infective therapy,rehabilitation and physiotherapy.At the same time,we also gave him the UCB-MSCs therapy by intravenous infusion.The recovery of consciousness,electroencephalogram,activity of daily living and follow-up results were observed during hospital stay.RESULTS AND CONCLUSION：One month later,the patient＇s motor and cognitive function recovered better.Electroencephalogram was rechecked.The a wave was observed.The activity of daily living scored 50 points.Seventy days later,follow-up showed that no adverse reaction was detectable,which suggested that stem cell therapy was safe in short period.These indicated that UCB-MSCs for hypoglycemic coma combined with hypoxic ischemic encephalopathy are safe and effective.