摘要
目的探讨检测外周血循环内皮细胞(CEC)在晚期食管癌放化疗疗效评估中的价值。方法 66例晚期食管鳞癌患者分为化疗组(21例,用PF方案)、放疗组(18例,剂量60~70 Gy/6周)和放化疗联合组(27例)。用流式细胞术检测外周血CEC。结果晚期食管癌患者CEC基础值较健康者高[(20.84±7.31)个/μl vs.(11.14±3.07)个/μl](P〈0.01)。治疗前,3组CEC数相仿;治疗后,放化疗联合组CEC较治疗前显著降低[(14.39±5.36)个/μl vs.(20.22±7.01)个/μl](P〈0.01),其他两组降低不明显。结论检测治疗前外周血CEC有可能成为预测晚期食管癌患者放化疗疗效的指标。
Objective To investigate the significance of detecting circulating endothelial cell(CEC)in evaluating the efficacy of radiochemotherapy in the patients with advanced esophageal cancer.Methods Sixty-six patients with advanced esophageal cancer were divided into groups of chemotherapy(group A,21 cases,PF regimen),radiotherapy(group B,18 cases,60~70 Gy/6w) and chemoradiotherapy(group C,27 cases).The CECs were detected with flow cytometry.Results The CECs were higher in the patients with advanced esophageal cancer than those in the healthy people [(20.84±7.31) pieces/μl vs.(11.14±3.07) pieces/μl](P0.01).Before treatment,the CECs of three groups were similar.The CECs of group C were lower after treatment than those before [(14.39±5.36) pieces/μl vs.(20.22±7.01) pieces/μl](P0.01),which were not significantly decreased in groups of A and B.Conclusion Detection of CECs in periphyral blood could be taken as a marker in evaluating the efficacy of radiochemotherapy in the patients with advanced esophageal cancer.
出处
《江苏医药》
CAS
CSCD
北大核心
2011年第7期792-794,共3页
Jiangsu Medical Journal
基金
江苏省"333工程"培养资金资助项目(苏人才办[2009]24号)
关键词
食管癌
循环内皮细胞
Esophageal cancer
Circulating endothelial cell