TgAb阳性时分化型甲状腺癌患者荷瘤状况分析及阳性TgAb对Tg临床价值的影响

Analysis of the status of loading metastatic lesions in DTC with positive TgAb and the effect of positive TgAb on the clinical value of Tg

目的分析甲状腺球蛋白抗体（TgAb）阳性时分化型甲状腺癌（DTC）患者荷瘤状况,间接评价阳性TgAb对甲状腺球蛋白（Tg）临床价值的影响。方法收集52例共69例次TgAb阳性DTC患者,对其131I治疗后的扫描结果进行分析,结合X线、CT、MRI、B超及临床随访等资料进行综合判断患者转移病灶的状况。有转移灶者为阳性。结果 Tg≥10μg/L、10~2.0μg/L、2~0.1μg/L、≤0.1μg/L 4组转移灶阳性率分别为80.95%、53.84%、58.82%、50.00%。组间差异无统计学意义（P〉0.05）。结论 TgAb阳性时,转移灶阳性率与Tg水平无相关性,阳性TgAb削弱了Tg的临床价值。

Objective To analyse the status of loading metastatic lesions in patients with differentiated thyroid cancer（DTC） with positive antithyroglobulin（P-TgAb） and evaluate the effect of P-TgAb on the clinical value of thyroglobulin（Tg） indirectly.Methods Data of 52 DTC patients with P-TgAb including 69 131I treatments were analyzed,which included scintigraphy after every 131I treatment X-ray,CT,MRI,B-type ultrasonography and follow-up.The positive rate of metastatic lesions was calculated.Results The positive rates of four groups of Tg≥10 μg/L,10～2.0 μg/L,2～0.1 μg/L and ≤0.1 μg/L were 80.95%,53.84%,58.82% and 50.00%,respectively（P0.05）.Conclusion When TgAb is positive,the positive rate of metastatic lesions is not correlated to the level of Tg.The P-TgAb reduces the clinical value of Tg.