摘要
目的探讨CD34在人肝细胞肝癌(HCC)组织中的表达及临床意义。方法对54例HCC及相应的癌旁肝组织标本进行了CD34免疫组织化学EnVisionTM法检测;对CD34标记的阳性血管进行肿瘤微血管密度(MVD)计数,分析临床病理特征。结果 CD34呈棕黄色染色定位于血管内皮细胞膜上,在HCC组织内显示弥漫的阳性表达;而癌旁肝组织多为阴性。HCC组织MVD值(46.23±16.12),明显高于癌旁肝组织的(18.15±5.92)(P<0.01)。HCC中CD34表达与EdmonsongradeⅢ+Ⅳ、静脉浸润、肝内外转移、肝硬化有关(P<0.05)。结论 HCC中CD34异常高表达,且与部分侵袭转移指标相关。
Objective To investigate the expression and clinical significance of CD34 in hepatocellular carcinoma（HCC）.Methods The expressions of CD34 in 54 specimens of HCC and tumor-adjacent liver tissues were detected by EnVisionTM immunohistochemistry.Microvascular density（MVD） in the CD34 positive cases was calculated and clinicopathological features of HCC were analyzed.Results The brown CD34 staining localized in the vascular endothelial cells,which was positively and diffusibly expressed in HCC tissues.The expression of CD34 in tumor-adjacent liver tissues was usually negative.MVD was significantly higher in HCC tissue than that in tumor-adjacent liver tissues（46.23±16.12 vs.18.15±5.92）（P0.01）.CD34 expression was correlated to Edmonson grade Ⅲ＋Ⅳ,vein invasion,metastasis and liver cirrhosis（P0.05）.ConclusionOverexpression of CD34 relates with angiogenesis,metastasis and invasion of HCC.
出处
《江苏医药》
CAS
CSCD
北大核心
2011年第7期836-838,共3页
Jiangsu Medical Journal
关键词
肝细胞肝癌
CD34
微血管密度
Hepatocellular carcinoma
CD34
Microvascular density
